Author, as appears in the article.: Hernáez Á; Soria-Florido MT; Castañer O; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Alonso-Gómez Á; Martínez-González MÁ; Schröder H; Ros E; Serra-Majem L; Fiol M; Lapetra J; Gomez-Gracia E; Fitó M; Lassale C
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Physical activity Lifestyle Hdl function Biomarkers lifestyle hdl function biomarkers
Abstract: © The European Society of Cardiology 2020. Aims: Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
Thematic Areas: Saúde coletiva Nutrição Medicine (all) Medicina ii Medicina i General medicine Epidemiology Engenharias iv Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20474873
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://journals.sagepub.com/doi/10.1177/2047487320925625
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Journal Of Preventive Cardiology. 28 (UNSP 2047487320925625): 2047487320925625-1401
APA: Hernáez Á; Soria-Florido MT; Castañer O; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Alonso-Gómez Á; Martínez-González MÁ; Schröder H; Ros E; Serr (2021). Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study. European Journal Of Preventive Cardiology, 28(UNSP 2047487320925625), 2047487320925625-1401. DOI: 10.1177/2047487320925625
Article's DOI: 10.1177/2047487320925625
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV