Author, as appears in the article.: Sprong C; Crépet A; Metruccio F; Blaznik U; Anagnostopoulos C; Christodoulou DL; Jensen BH; Kennedy M; González N; Rehurkova I; Ruprich J; te Biesebeek JD; Vanacker M; Moretto A; van Klaveren J
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Gonzalez Paradell, Nieves
Keywords: Pesticides Persistent organic pollutants Pcbs Margin of exposure Food additives Dioxins Dietary exposure Cumulative risk assessment Chemical mixtures persistent organic pollutants margin of exposure food additives dietary exposure cumulative risk assessment chemical mixtures
Abstract: © 2020 Elsevier Ltd Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic combined dietary exposure was assessed for adults and children of nine European countries following the most commonly used exposure methodologies in Europe and by using a relative potency factor approach. For risk characterization, a Margin of Exposure (MOE) was calculated. To overarch the risk across silos, a normalised combined margin of exposure (nMOET) approach was proposed. This case study demonstrated that risk assessment of combined exposure to chemicals can be performed within regulatory silos. It also highlighted important differences in the conservatism of exposure scenarios, the derivation of point of departures and the subsequent acceptable MOEs between the silos. To overarch the risk despite these differences, a nMOET approach can be used.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nieves.gonzalez@urv.cat
Author identifier: 0000-0003-4134-016X
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691520303069?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food And Chemical Toxicology. 142 (111416): 111416-
APA: Sprong C; Crépet A; Metruccio F; Blaznik U; Anagnostopoulos C; Christodoulou DL; Jensen BH; Kennedy M; González N; Rehurkova I; Ruprich J; te Biesebee (2020). Cumulative dietary risk assessment overarching different regulatory silos using a margin of exposure approach: A case study with three chemical silos. Food And Chemical Toxicology, 142(111416), 111416-. DOI: 10.1016/j.fct.2020.111416
Article's DOI: 10.1016/j.fct.2020.111416
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV