Articles producció científica> Medicina i Cirurgia

Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease

  • Identification data

    Identifier: imarina:6494822
    Authors:
    Daimiel LMicó VValls RMPedret AMotilva MJRubió LFitó MFarrás MCovas MISolá ROrdovás JM
    Abstract:
    This article is protected by copyright. All rights reserved. SCOPE: We aimed to investigate the postprandial modulation of cardiovascular-related microRNAs elicited by Extra Virgin Olive oil (EVOOs) containing different levels of own polyphenols METHODS AND RESULTS: Randomized, postprandial, parallel, double-blind study. 12 healthy participants consumed 30 mL of EVOO containing Low (L-EVOO; 250 mg total phenols/kg of oil), Medium (M-EVOO; 500 mg total phenols/kg of oil) and high (H-EVOO; 750 mg total phenols/kg of oil) polyphenol content to 6 h. Plasma microRNAs levels were analysed by Real-Time quantitative PCR. The results show that L-EVOO intake was associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreased plasma let-7e-5p and increased miR-17-5p, miR-20a-5p and miR-192-5p levels. Finally, H-EVOO decreased let-7e-5p, miR-10a-5p, miR-21-5p and miR-26b-5p levels. CONCLUSIONS: During the postprandial state, the levels of let-7e-5p decreased with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol/kg olive oil. Moreover, the miR-17-92 cluster increased by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake. This article is protected by copyright. All rights reserved.
  • Others:

    Author, as appears in the article.: Daimiel L; Micó V; Valls RM; Pedret A; Motilva MJ; Rubió L; Fitó M; Farrás M; Covas MI; Solá R; Ordovás JM
    Department: Medicina i Cirurgia
    URV's Author/s: Pedret Figuerola, Anna / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Keywords: Signature Risk Quality Polyphenols Micrornas Mediterranean diet Gene Extra virgin olive oil Expression Colon Cluster Cells Cardiovascular disease Biomarkers mediterranean diet extra virgin olive oil cardiovascular disease biomarkers
    Abstract: This article is protected by copyright. All rights reserved. SCOPE: We aimed to investigate the postprandial modulation of cardiovascular-related microRNAs elicited by Extra Virgin Olive oil (EVOOs) containing different levels of own polyphenols METHODS AND RESULTS: Randomized, postprandial, parallel, double-blind study. 12 healthy participants consumed 30 mL of EVOO containing Low (L-EVOO; 250 mg total phenols/kg of oil), Medium (M-EVOO; 500 mg total phenols/kg of oil) and high (H-EVOO; 750 mg total phenols/kg of oil) polyphenol content to 6 h. Plasma microRNAs levels were analysed by Real-Time quantitative PCR. The results show that L-EVOO intake was associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreased plasma let-7e-5p and increased miR-17-5p, miR-20a-5p and miR-192-5p levels. Finally, H-EVOO decreased let-7e-5p, miR-10a-5p, miR-21-5p and miR-26b-5p levels. CONCLUSIONS: During the postprandial state, the levels of let-7e-5p decreased with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol/kg olive oil. Moreover, the miR-17-92 cluster increased by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake. This article is protected by copyright. All rights reserved.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Author's mail: anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat
    Author identifier: 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942
    Record's date: 2023-02-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202000049?casa_token=0IEwFxmocNIAAAAA%3AmEe_APPU2RO22IEtypvXjB3pCiTShWCRstIo59XPxtDRJI8NftZc25pjT9AFDhbVfMMVHWYegFG5HA
    Papper original source: Molecular Nutrition & Food Research. 64 (2000049): e2000049-
    APA: Daimiel L; Micó V; Valls RM; Pedret A; Motilva MJ; Rubió L; Fitó M; Farrás M; Covas MI; Solá R; Ordovás JM (2020). Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease. Molecular Nutrition & Food Research, 64(2000049), e2000049-. DOI: 10.1002/mnfr.202000049
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1002/mnfr.202000049
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Signature
    Risk
    Quality
    Polyphenols
    Micrornas
    Mediterranean diet
    Gene
    Extra virgin olive oil
    Expression
    Colon
    Cluster
    Cells
    Cardiovascular disease
    Biomarkers
    mediterranean diet
    extra virgin olive oil
    cardiovascular disease
    biomarkers
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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