Author, as appears in the article.: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H
Department: Enginyeria Química
URV's Author/s: Kumar, Vikas / Martínez Rodríguez, María Ángeles
Keywords: Young adult Serum Phthalates Performance liquid-chromatography Pbpk Parabens Norway Molecular structure Models, biological Middle aged Male Humans Human biomonitoring Foods Food contamination Female Exposure Esters Diethylhexyl phthalate Diet Dehp Cosmetics Children Catalonia Bisphenol-a Biological monitoring Aged Adult
Abstract: © 2020 The Author(s) Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball©. Simulated urinary concentrations using physiologically based pharmacokinetic (PBPK) models were compared with measured urinary metabolites of DEHP, mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono-2-ethyl 5-carboxypentyl phthalate (MECCP). DEHP exposure from food are approximately 10 times higher than exposure than from PCPs. The main contributors to dietary exposure are dairy, grain, fruits and vegetables, meat and fish. Body lotion contribute most to the exposure of DEHP from PCPs. Forward-dosimetry gives good convergence with 24-h urinary concentrations of simulated and measured BM data. The measured concentration of the MECCP metabolite correlated well with simulated high exposure, while the measured concentrations of MEHP, MEHHP and MEOHP partly overlapped with both simulated low, medium and high metabolite exposure.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0278-6915
Author's mail: vikas.kumar@urv.cat mangeles.martinez@urv.cat
Author identifier: 0000-0002-9795-5967 0000-0001-8595-3772
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/publishedVersion
Papper original source: Food And Chemical Toxicology. 143 (111510): 111510-
APA: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H (2020). Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Food And Chemical Toxicology, 143(111510), 111510-. DOI: 10.1016/j.fct.2020.111510
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV