Articles producció científica> Bioquímica i Biotecnologia

Long Term Exposure to a Grape Seed Proanthocyanidin Extract Enhances L-Cell Differentiation in Intestinal Organoids

  • Identification data

    Identifier: imarina:6817717
    Handle: http://hdl.handle.net/20.500.11797/imarina6817717
  • Authors:

    Casanova-Marti, Angela
    Gonzalez-Abuin, Noemi
    Serrano, Joan
    Blay, Maria Teresa
    Terra, Ximena
    Frost, Gary
    Pinent, Montserrat
    Ardevol, Anna
  • Others:

    Author, as appears in the article.: Casanova-Marti, Angela; Gonzalez-Abuin, Noemi; Serrano, Joan; Blay, Maria Teresa; Terra, Ximena; Frost, Gary; Pinent, Montserrat; Ardevol, Anna;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardèvol Grau, Anna / Blay Olivé, Maria Teresa / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
    Keywords: Secretion Proanthocyanidins Proanthocyanidins Inhibition Incretin Htas2r14 Gut Green tea Glucagon-like peptide-1 Enteroendocrine Endocrine cell Decrease Bitter-taste receptor Activation incretin glucagon-like peptide-1 enteroendocrine
    Abstract: Scope A grape-seed proanthocyanidin extract (GSPE) interacts at the intestinal level, enhancing glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) release, which modulate appetite and glucose homeostasis. Thus, enhancing L-cell numbers could be a strategy to promote hormone production, providing a potential strategy for obesity and type-2 diabetes mellitus (T2DM) treatment. Methods and results Mice ileum organoids are used to evaluate the long-term effects of GSPE and two of its main components, epicatechin (EC) and gallic acid (GA), on intestinal differentiation. Hormone levels are determined using RIA and ELISA kits, and gene expression of transcription factors involved in intestinal cell differentiation, as well as markers of different cell types, are assessed by real-time qPCR. GSPE upregulates enterohormone gene expression and content, as well as the pan-endocrine marker chromogranin A. GSPE also modulates the temporal gene expression profile of early and late transcription factors involved in L-cell differentiation. Furthermore, GSPE upregulates goblet cell (Muc2) and enterocyte (sucraseisomaltase) markers, while downregulating stem cell markers (Lgr5+). Although EC and GA modified enterohormone release, they do not reproduce GSPE effects on transcription factor's profile. Conclusions This study shows the potential role of GSPE in promoting enteroendocrine differentiation, effect that is not mediated by EC or GA.
    Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1613-4125
    Author's mail: ximena.terra@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat
    Author identifier: 0000-0003-1043-5844 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538
    Record's date: 2023-02-27
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.202000303
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Molecular Nutrition & Food Research. 64 (2000303): e2000303-
    APA: Casanova-Marti, Angela; Gonzalez-Abuin, Noemi; Serrano, Joan; Blay, Maria Teresa; Terra, Ximena; Frost, Gary; Pinent, Montserrat; Ardevol, Anna; (2020). Long Term Exposure to a Grape Seed Proanthocyanidin Extract Enhances L-Cell Differentiation in Intestinal Organoids. Molecular Nutrition & Food Research, 64(2000303), e2000303-. DOI: 10.1002/mnfr.202000303
    Article's DOI: 10.1002/mnfr.202000303
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology,Food Science,Food Science & Technology
    Secretion
    Proanthocyanidins
    Proanthocyanidins
    Inhibition
    Incretin
    Htas2r14
    Gut
    Green tea
    Glucagon-like peptide-1
    Enteroendocrine
    Endocrine cell
    Decrease
    Bitter-taste receptor
    Activation
    incretin
    glucagon-like peptide-1
    enteroendocrine
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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