Articles producció científica> Medicina i Cirurgia

Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort

  • Identification data

    Identifier: imarina:6818082
    Authors:
    Estrada, VicenteGeijo, PalomaFuentes-Ferrer, ManuelGarcia Alcalde, Maria LuisaRodrigo, MariaJose Galindo, MariaMunoz, AgustinDomingo, PereRibera, EsteveCosin, JaimeViciana, PompeyoLozano, FernandoTerron, AlbertoVergara, AntonioTeira, RamonMunoz-Sanchez, JosefaRoca, BernardinoSanchez, TrinitarioLopez-Aldeguer, JoseDeig, ElisabethVidal, FranciscoPedrol, EnricCastano-Carracedo, ManuelPuig, TeresaGarrido, MyriamSuarez-Lozano, Ignacio
    Abstract:
    Background: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio.
  • Others:

    Author, as appears in the article.: Estrada, Vicente; Geijo, Paloma; Fuentes-Ferrer, Manuel; Garcia Alcalde, Maria Luisa; Rodrigo, Maria; Jose Galindo, Maria; Munoz, Agustin; Domingo, Pere; Ribera, Esteve; Cosin, Jaime; Viciana, Pompeyo; Lozano, Fernando; Terron, Alberto; Vergara, Antonio; Teira, Ramon; Munoz-Sanchez, Josefa; Roca, Bernardino; Sanchez, Trinitario; Lopez-Aldeguer, Jose; Deig, Elisabeth; Vidal, Francisco; Pedrol, Enric; Castano-Carracedo, Manuel; Puig, Teresa; Garrido, Myriam; Suarez-Lozano, Ignacio;
    Department: Medicina i Cirurgia
    URV's Author/s: Vidal Marsal, Francisco
    Keywords: Trends Stress Lipid abnormalities Hepatitis-c virus Haart Gender Efavirenz Cardiovascular risk Atherosclerosis
    Abstract: Background: Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods: Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results: Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions: In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio.
    Thematic Areas: Sociologia i política Saúde coletiva Reproductive medicine Public, environmental & occupational health Psicología Obstetrics and gynecology Obstetrics & gynecology Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General o multidisciplinar General medicine Enfermagem Educação física Educação Economia Direito Ciencias sociales Ciências biológicas ii Biotecnología Antropologia / arqueologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1472-6874
    Author's mail: francesc.vidal@urv.cat
    Author identifier: 0000-0002-6692-6186
    Record's date: 2023-02-19
    Journal volume: 11
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcwomenshealth.biomedcentral.com/articles/10.1186/1472-6874-11-36
    Papper original source: Bmc Womens Health. 11 (36): 36-
    APA: Estrada, Vicente; Geijo, Paloma; Fuentes-Ferrer, Manuel; Garcia Alcalde, Maria Luisa; Rodrigo, Maria; Jose Galindo, Maria; Munoz, Agustin; Domingo, Pe (2011). Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort. Bmc Womens Health, 11(36), 36-. DOI: 10.1186/1472-6874-11-36
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1186/1472-6874-11-36
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2011
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Obstetrics & Gynecology,Obstetrics and Gynecology,Public, Environmental & Occupational Health,Reproductive Medicine
    Trends
    Stress
    Lipid abnormalities
    Hepatitis-c virus
    Haart
    Gender
    Efavirenz
    Cardiovascular risk
    Atherosclerosis
    Sociologia i política
    Saúde coletiva
    Reproductive medicine
    Public, environmental & occupational health
    Psicología
    Obstetrics and gynecology
    Obstetrics & gynecology
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General o multidisciplinar
    General medicine
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Ciencias sociales
    Ciências biológicas ii
    Biotecnología
    Antropologia / arqueologia
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