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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

  • Identification data

    Identifier: imarina:7067377
    Authors:
    Autrup, HermanBarile, Frank A.Berry, Sir ColinBlaauboer, Bas J.Boobis, AlanBolt, HerrmannBorgert, Christopher J.Dekant, WolfgangDietrich, DanielDomingo, Jose L.Gori, Gio BattaGreim, HelmutHengstler, JanKacew, SamMarquardt, HansPelkonen, OlaviSavolainen, KaiHeslop-Harrison, PatVermeulen, Nico P.
    Abstract:
    Theoretically, both synthetic endocrine-disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine-disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea, and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should usein vitrotests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
  • Others:

    Author, as appears in the article.: Autrup, Herman; Barile, Frank A.; Berry, Sir Colin; Blaauboer, Bas J.; Boobis, Alan; Bolt, Herrmann; Borgert, Christopher J.; Dekant, Wolfgang; Dietrich, Daniel; Domingo, Jose L.; Gori, Gio Batta; Greim, Helmut; Hengstler, Jan; Kacew, Sam; Marquardt, Hans; Pelkonen, Olavi; Savolainen, Kai; Heslop-Harrison, Pat; Vermeulen, Nico P.;
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Domingo Roig, José Luis
    Keywords: Uncertainty Toxicology Testing Science Risk characterization Modulators Impact Human health Eu Estrogens Endocrine disruption Bisphenol-a
    Abstract: Theoretically, both synthetic endocrine-disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine-disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea, and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should usein vitrotests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
    Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Public, environmental & occupational health Psicología Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências General medicine Farmacia Environmental sciences Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Arquitetura, urbanismo e design
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joseluis.domingo@urv.cat
    Author identifier: 0000-0001-6647-9470
    Record's date: 2023-02-23
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.tandfonline.com/doi/full/10.1080/15287394.2020.1756592
    Papper original source: Journal Of Toxicology And Environmental Health-Part A-Current Issues. 83 (13-14): 485-494
    APA: Autrup, Herman; Barile, Frank A.; Berry, Sir Colin; Blaauboer, Bas J.; Boobis, Alan; Bolt, Herrmann; Borgert, Christopher J.; Dekant, Wolfgang; Dietri (2020). Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Journal Of Toxicology And Environmental Health-Part A-Current Issues, 83(13-14), 485-494. DOI: 10.1080/15287394.2020.1756592
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1080/15287394.2020.1756592
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Public, Environmental & Occupational Health,Toxicology
    Uncertainty
    Toxicology
    Testing
    Science
    Risk characterization
    Modulators
    Impact
    Human health
    Eu
    Estrogens
    Endocrine disruption
    Bisphenol-a
    Zootecnia / recursos pesqueiros
    Toxicology
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Psicología
    Odontología
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Health, toxicology and mutagenesis
    Geografía
    Geociências
    General medicine
    Farmacia
    Environmental sciences
    Engenharias i
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Arquitetura, urbanismo e design
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