Author, as appears in the article.: Autrup, Herman; Barile, Frank A.; Berry, Sir Colin; Blaauboer, Bas J.; Boobis, Alan; Bolt, Herrmann; Borgert, Christopher J.; Dekant, Wolfgang; Dietrich, Daniel; Domingo, Jose L.; Gori, Gio Batta; Greim, Helmut; Hengstler, Jan; Kacew, Sam; Marquardt, Hans; Pelkonen, Olavi; Savolainen, Kai; Heslop-Harrison, Pat; Vermeulen, Nico P.;

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Domingo Roig, José Luis

Keywords: Uncertainty Toxicology Testing Science Risk characterization Modulators Impact Human health Eu Estrogens Endocrine disruption Bisphenol-a

Abstract: Theoretically, both synthetic endocrine-disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine-disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea, and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should usein vitrotests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.

Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Public, environmental & occupational health Psicología Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências General medicine Farmacia Environmental sciences Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Arquitetura, urbanismo e design

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: joseluis.domingo@urv.cat

Author identifier: 0000-0001-6647-9470

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.tandfonline.com/doi/full/10.1080/15287394.2020.1756592

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Toxicology And Environmental Health-Part A-Current Issues. 83 (13-14): 485-494

APA: Autrup, Herman; Barile, Frank A.; Berry, Sir Colin; Blaauboer, Bas J.; Boobis, Alan; Bolt, Herrmann; Borgert, Christopher J.; Dekant, Wolfgang; Dietri (2020). Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Journal Of Toxicology And Environmental Health-Part A-Current Issues, 83(13-14), 485-494. DOI: 10.1080/15287394.2020.1756592

Article's DOI: 10.1080/15287394.2020.1756592

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications