Articles producció científica> Bioquímica i Biotecnologia

A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats

  • Identification data

    Identifier: imarina:7486144
    Authors:
    Miguel Z Martín-GonzálezHéctor Palacios-JordanMaria IbarsAndrea Ardid-RuizAlbert Gibert-RamosMiguel A RodríguezManuel SuárezBegoña MuguerzaGerard Aragonès
    Abstract:
    The use of a single family of dietary bioactive compounds has not been sufficient to manage highly regulated mechanisms such as body weight. Therefore, we aimed to evaluate the effect of a multifunctional ingredient (MIX) based on the co-administration of a low dose of conjugated linoleic acid with the protein hydrolysate from chicken feet, Hpp11, and a mixture of grape-seed proanthocyanidins and berry anthocyanins on body weight management in obese rats fed a cafeteria diet. The daily oral administration of the MIX for three weeks significantly reversed obesity and hyperleptinemia and increased energy expenditure and fat oxidation. In addition, animals administered the MIX exhibited greater hypothalamic activation of STAT3 in POMC-expressing neurons than non-supplemented animals. Our results strongly suggest that the co-administration of different bioactive compounds could be a promising strategy to complement the existing therapies against obesity and leptin resistance.
  • Others:

    Author, as appears in the article.: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Muguerza; Gerard Aragonès
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Aragonès Bargalló, Gerard / ARDID RUIZ, ANDREA / GIBERT RAMOS, ALBERT / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Rodríguez Gómez, Miquel Àngel / Suárez Recio, Manuel
    Keywords: Supplementation Resistance Protein Proanthocyanidins Obesity Multi-ingredient Liver Inhibition Induced obesity Hypothalamic sirt1 Fat Conjugated linoleic-acid Conjugated linoleic acid Bioactive peptides Anthocyanidins
    Abstract: The use of a single family of dietary bioactive compounds has not been sufficient to manage highly regulated mechanisms such as body weight. Therefore, we aimed to evaluate the effect of a multifunctional ingredient (MIX) based on the co-administration of a low dose of conjugated linoleic acid with the protein hydrolysate from chicken feet, Hpp11, and a mixture of grape-seed proanthocyanidins and berry anthocyanins on body weight management in obese rats fed a cafeteria diet. The daily oral administration of the MIX for three weeks significantly reversed obesity and hyperleptinemia and increased energy expenditure and fat oxidation. In addition, animals administered the MIX exhibited greater hypothalamic activation of STAT3 in POMC-expressing neurons than non-supplemented animals. Our results strongly suggest that the co-administration of different bioactive compounds could be a promising strategy to complement the existing therapies against obesity and leptin resistance.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 17564646
    Author's mail: begona.muguerza@urv.cat gerard.aragones@urv.cat miquelangel.rodriguez@alumni.urv.cat manuel.suarez@urv.cat
    Author identifier: 0000-0001-7384-8588 0000-0003-0122-8253
    Record's date: 2023-12-16
    Journal volume: 73
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464620303650?via%3Dihub
    Papper original source: Journal Of Functional Foods. 73 (104141):
    APA: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Mugue (2020). A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats. Journal Of Functional Foods, 73(104141), -. DOI: 10.1016/j.jff.2020.104141
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.jff.2020.104141
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Supplementation
    Resistance
    Protein
    Proanthocyanidins
    Obesity
    Multi-ingredient
    Liver
    Inhibition
    Induced obesity
    Hypothalamic sirt1
    Fat
    Conjugated linoleic-acid
    Conjugated linoleic acid
    Bioactive peptides
    Anthocyanidins
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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