Author, as appears in the article.: Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arenas Prat, Meritxell / Espinas Pinol, Josep Alfons
Keywords: Treatment time Survival Spain Retrospective studies Radiation treatment Prostate Proportional hazards models Persistence Middle aged Male Interruptions Humans Female External radiotherapy Dose Breast neoplasms Barriers Adherence
Abstract: This study aims to assess the effects of non-adherence to external beam radiation therapy in cancer patients receiving treatment with a curative intent.This retrospective cohort study collected health records data for all cancer patients treated with external beam radiotherapy with curative intent in 2016 in Catalonia, Spain. Adherence was defined as having received at least 90% of the total dose prescribed. A logistic regression model was used to assess factors related to non-adherence, and its association with one-year survival was evaluated using Cox regression.The final sample included 8721 patients (mean age 63.6 years): breast cancer was the most common tumour site (38.1%), followed by prostate and colon/rectum. Treatment interruptions prolonged the total duration of therapy in 70.7% of the patients, and 1.0% were non-adherent. Non-adherence was associated with advanced age, female gender, and some localization of primary tumour (head and neck, urinary bladder, and haematological cancers). The risk of death in non-adherent patients was higher than in adherent patients (hazard ratio [HR] 1.63, 95% confidence interval 0.97 to 2.74), after adjusting for the potential confounding effect of age, gender, tumour site and comorbidity.Non-adherence to radiotherapy, as measured by the received dose, is very low in our setting, and it may have an impact on one-year survival.Copyright © 2020. Published by Elsevier B.V.
Thematic Areas: Saúde coletiva Radiology, nuclear medicine and imaging Radiology, nuclear medicine & medical imaging Oncology Odontología Medicina ii Medicina i Interdisciplinar Hematology General medicine Engenharias iv Engenharias ii Ciências biológicas ii Ciências biológicas i Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: meritxell.arenas@urv.cat
Author identifier: 0000-0003-0815-2570
Record's date: 2024-09-28
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Radiotherapy And Oncology. 151 200-205
APA: Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA (2020). Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in catalonia, spain. Radiotherapy And Oncology, 151(), 200-205. DOI: 10.1016/j.radonc.2020.08.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV