Articles producció científica> Ciències Mèdiques Bàsiques

Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in catalonia, spain

  • Identification data

    Identifier: imarina:7508022
    Authors:
    Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA
    Abstract:
    This study aims to assess the effects of non-adherence to external beam radiation therapy in cancer patients receiving treatment with a curative intent.This retrospective cohort study collected health records data for all cancer patients treated with external beam radiotherapy with curative intent in 2016 in Catalonia, Spain. Adherence was defined as having received at least 90% of the total dose prescribed. A logistic regression model was used to assess factors related to non-adherence, and its association with one-year survival was evaluated using Cox regression.The final sample included 8721 patients (mean age 63.6 years): breast cancer was the most common tumour site (38.1%), followed by prostate and colon/rectum. Treatment interruptions prolonged the total duration of therapy in 70.7% of the patients, and 1.0% were non-adherent. Non-adherence was associated with advanced age, female gender, and some localization of primary tumour (head and neck, urinary bladder, and haematological cancers). The risk of death in non-adherent patients was higher than in adherent patients (hazard ratio [HR] 1.63, 95% confidence interval 0.97 to 2.74), after adjusting for the potential confounding effect of age, gender, tumour site and comorbidity.Non-adherence to radiotherapy, as measured by the received dose, is very low in our setting, and it may have an impact on one-year survival.Copyright © 2020. Published by Elsevier B.V.
  • Others:

    Author, as appears in the article.: Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell / Espinas Pinol, Josep Alfons
    Keywords: Treatment time Survival Spain Retrospective studies Radiation treatment Prostate Proportional hazards models Persistence Middle aged Male Interruptions Humans Female External radiotherapy Dose Breast neoplasms Barriers Adherence
    Abstract: This study aims to assess the effects of non-adherence to external beam radiation therapy in cancer patients receiving treatment with a curative intent.This retrospective cohort study collected health records data for all cancer patients treated with external beam radiotherapy with curative intent in 2016 in Catalonia, Spain. Adherence was defined as having received at least 90% of the total dose prescribed. A logistic regression model was used to assess factors related to non-adherence, and its association with one-year survival was evaluated using Cox regression.The final sample included 8721 patients (mean age 63.6 years): breast cancer was the most common tumour site (38.1%), followed by prostate and colon/rectum. Treatment interruptions prolonged the total duration of therapy in 70.7% of the patients, and 1.0% were non-adherent. Non-adherence was associated with advanced age, female gender, and some localization of primary tumour (head and neck, urinary bladder, and haematological cancers). The risk of death in non-adherent patients was higher than in adherent patients (hazard ratio [HR] 1.63, 95% confidence interval 0.97 to 2.74), after adjusting for the potential confounding effect of age, gender, tumour site and comorbidity.Non-adherence to radiotherapy, as measured by the received dose, is very low in our setting, and it may have an impact on one-year survival.Copyright © 2020. Published by Elsevier B.V.
    Thematic Areas: Saúde coletiva Radiology, nuclear medicine and imaging Radiology, nuclear medicine & medical imaging Oncology Odontología Medicina ii Medicina i Interdisciplinar Hematology General medicine Engenharias iv Engenharias ii Ciências biológicas ii Ciências biológicas i Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: meritxell.arenas@urv.cat
    Author identifier: 0000-0003-0815-2570
    Record's date: 2024-09-28
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.thegreenjournal.com/article/S0167-8140(20)30718-0/fulltext
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Radiotherapy And Oncology. 151 200-205
    APA: Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA (2020). Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in catalonia, spain. Radiotherapy And Oncology, 151(), 200-205. DOI: 10.1016/j.radonc.2020.08.002
    Article's DOI: 10.1016/j.radonc.2020.08.002
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Hematology,Oncology,Radiology, Nuclear Medicine & Medical Imaging,Radiology, Nuclear Medicine and Imaging
    Treatment time
    Survival
    Spain
    Retrospective studies
    Radiation treatment
    Prostate
    Proportional hazards models
    Persistence
    Middle aged
    Male
    Interruptions
    Humans
    Female
    External radiotherapy
    Dose
    Breast neoplasms
    Barriers
    Adherence
    Saúde coletiva
    Radiology, nuclear medicine and imaging
    Radiology, nuclear medicine & medical imaging
    Oncology
    Odontología
    Medicina ii
    Medicina i
    Interdisciplinar
    Hematology
    General medicine
    Engenharias iv
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Astronomia / física
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