Author, as appears in the article.: Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Boque, Noemi; Puiggros, Francesc; Valls, Rosa-M; Pedret, Anna; Manuel Llabres, Josep; Arola, Lluis; Sola, Rosa;
Department: Medicina i Cirurgia
URV's Author/s: Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Turmeric extracts Treatment outcome Symptoms Randomized controlled trial Plant extracts Plant extract Painkiller Pain Osteoarthritis, knee Metaanalysis Knee osteoarthritis Knee joint pain Knee joint Knee Humans Human Formulation Double-blind method Double-blind Double blind procedure Curcumin Curcuma longa Curcuma Controlled study Clinical-use Brewer's yeast Arthritis Arthralgia painkiller knee joint pain curcuma longa brewer's yeast
Abstract: Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive(R)) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (P < .01), going up or down stairs (P < .001), and sitting or lying (P < .05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (P < .01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (P < .001), being less with B-Turmactive after 1 week (P = .012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (P = .045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.
Thematic Areas: Zootecnia / recursos pesqueiros Química Planejamento urbano e regional / demografia Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Farmacia Ensino Engenharias iv Engenharias ii Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1096620X
Author's mail: lorena.calderon@urv.cat judit.companys@urv.cat anna.pedret@urv.cat elisabet.llaurado@urv.cat judit.companys@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0003-0766-0733 0000-0003-1485-0818 0000-0002-5327-932X 0000-0002-7439-9531 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.liebertpub.com/doi/full/10.1089/jmf.2020.0074
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Medicinal Food. 24 (4): 436-440
APA: Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Boque, Noemi; Puiggros, Francesc; Valls, Rosa-M; Pedret, Anna; Manuel Ll (2021). Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial. Journal Of Medicinal Food, 24(4), 436-440. DOI: 10.1089/jmf.2020.0074
Article's DOI: 10.1089/jmf.2020.0074
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV