Author, as appears in the article.: Martinez-Micaelo, Neus; Ligero, Carme; Antequera-Gonzalez, Borja; Junza, Alexandra; Yanes, Oscar; Alegret, Josep M
Department: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
URV's Author/s: Alegret Colomé, Josep Maria / Antequera González, Borja / Junza Martínez, Alexandra / Martínez Micaelo, Nieves Beatriz / Yanes Torrado, Óscar
Keywords: Wall shear-stress Tocopherol Metabolomics Lipid-metabolism Inflammation Flow patterns Dilatation Choline Bicuspid aortic valve Ascending aortic dilation Antioxidant Alpha-tocopherol inflammation bicuspid aortic valve ascending aortic dilation antioxidant alpha-tocopherol
Abstract: Background: The bicuspid aortic valve (BAV) is the most common cardiac congenital disease and is associated with an increased risk of developing ascending aorta dilation; which can have fatal consequences. Currently; no established risk biomarkers exist to facilitate the diagnosis and prognosis of BAV. Methods: Using an untargeted metabolomic approach; we identified the levels of metabolites in plasma samples and compared them depending on the bicuspid or tricuspid morphology of the aortic valve. Including those patients with ascending aortic dilation and/or aortic stenosis (n= 212), we analyzed the role possibly played by alpha-Tocopherol in BAV disease; considering its association with the pathophysiological characteristics of BAV and biomarkers related to inflammation, oxidative stress and endothelial damage, as well as characteristics related to alpha-Tocopherol functionality and metabolism. Results: We found that BAV patients; especially those with ascending aortic dilation; presented lower antioxidant capacity; as determined by decreased plasma levels of alpha-Tocopherol; paraoxonase 1 and high-density lipoprotein (HDL), as well as increased levels of C-reactive protein (CRP; a biomarker of inflammation) and endothelial microparticles (EMPs; an endothelial damage biomarker). By applying random forest analyses; we evaluated the significant screening capacity of alpha-Tocopherol; CRP and EMPs to classify patients depending on the morphology of the aortic valve. Discussion: Our findings support the role of decreased antioxidant capacity; increased inflammation and endothelial damage in the pathogenesis of BAV and the progression of aortic dilation. Moreover; determining the plasma levels of alpha-Tocopherol; CRP and EMPs could improve BAV diagnosis in large populations.
Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20770383
Author's mail: oscar.yanes@urv.cat neus.martinez@urv.cat alexandra.junza@urv.cat borja.antequera@estudiants.urv.cat borja.antequera@estudiants.urv.cat josepmaria.alegret@urv.cat
Author identifier: 0000-0003-3695-7157 0000-0001-7205-0419 0000-0002-6117-5512
Record's date: 2024-10-12
Journal volume: 9
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/9/7/2215
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Clinical Medicine. 9 (7): 2215-12
APA: Martinez-Micaelo, Neus; Ligero, Carme; Antequera-Gonzalez, Borja; Junza, Alexandra; Yanes, Oscar; Alegret, Josep M (2020). Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity dagger. Journal Of Clinical Medicine, 9(7), 2215-12. DOI: 10.3390/jcm9072215
Article's DOI: 10.3390/jcm9072215
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications