Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

Identifier:  imarina:7980030

Handle: https://hdl.handle.net/20.500.11797/imarina7980030

Authors:  Navarrete-Munoz, Eva-Maria; Vioque, Jesus; Toledo, Estefania; Oncina-Canovas, Alejando; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montserrat; Romaguera, Dora; Alonso-Gomez, Angel M; Warnberg, Julia; Alfredo Martinez, J; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Bueno-Cavanillas, Aurora; Matia-Martin, Pilar; Daimiel, Lidia; Martin Sanchez, Vicente; Vidal, Josep; de Cos Blanco, Ana Isabel; Ros, Emili; Diez-Espino, Javier; Babio, Nancy; Fernandez-Carrion, Rebeca; Castaner, Olga; Colom, Antoni; Compan-Gabucio, Laura; Salaverria Lete, Itziar; Crespo-Oliva, Edelys; Abete, Itziar; Tomaino, Laura; Casas, Rosa; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Sarasa, Iziar; Antonio Garcia-Rios, Jose M; Martin-Pelaez, Sandra; Ruiz-Canela, Miguel; Diaz-Lopez, Andres; Martinez-Lacruz, Raul; Dolors Zomeno, Maria; Rayo, Elena; Gisbert Selles, Cristina; Canudas, Silvia; Goday, Albert; Garcia-de-la-Hera, Manoli

Abstract:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.