Articles producció científica> Bioquímica i Biotecnologia

Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study

  • Identification data

    Identifier: imarina:7980030
    Authors:
    Navarrete-Muñoz EMVioque JToledo EOncina-Canovas AMartínez-González MÁSalas-Salvadó JCorella DFitó MRomaguera DAlonso-Gómez ÁMWärnberg JMartínez JASerra-Majem LEstruch RTinahones FJLapetra JPintó XTur JALópez-Miranda JBueno-Cavanillas AMatía-Martín PDaimiel LSánchez VMVidal Jde Cos Blanco AIRos EDiez-Espino JBabio NFernandez-Carrion RCastañer OColom ACompañ-Gabucio LLete ISCrespo-Oliva EAbete ITomaino LCasas RFernandez-Garcia JCSantos-Lozano JMSarasa I
    Abstract:
    © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
  • Others:

    Author, as appears in the article.: Navarrete-Muñoz EM; Vioque J; Toledo E; Oncina-Canovas A; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Bueno-Cavanillas A; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; de Cos Blanco AI; Ros E; Diez-Espino J; Babio N; Fernandez-Carrion R; Castañer O; Colom A; Compañ-Gabucio L; Lete IS; Crespo-Oliva E; Abete I; Tomaino L; Casas R; Fernandez-Garcia JC; Santos-Lozano JM; Sarasa I
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Díaz López, Andres / Salas Salvadó, Jorge
    Keywords: Stress Risk Prevalence Metabolic syndrome score Metaanalysis Insulin-resistance Homocysteine Folic-acid supplementation Folate Diseases Diabetes Cholesterol Cardiometabolic risk Association Adults folate diabetes cholesterol cardiometabolic risk
    Abstract: © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
    Thematic Areas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14366207
    Author's mail: andres.diaz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-7500-5629 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://link.springer.com/article/10.1007/s00394-020-02364-4
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: European Journal Of Nutrition. 60 (2): 1125-1136
    APA: Navarrete-Muñoz EM; Vioque J; Toledo E; Oncina-Canovas A; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Alonso-Gómez ÁM; Wärn (2021). Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. European Journal Of Nutrition, 60(2), 1125-1136. DOI: 10.1007/s00394-020-02364-4
    Article's DOI: 10.1007/s00394-020-02364-4
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Stress
    Risk
    Prevalence
    Metabolic syndrome score
    Metaanalysis
    Insulin-resistance
    Homocysteine
    Folic-acid supplementation
    Folate
    Diseases
    Diabetes
    Cholesterol
    Cardiometabolic risk
    Association
    Adults
    folate
    diabetes
    cholesterol
    cardiometabolic risk
    Serviço social
    Saúde coletiva
    Química
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
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