Author, as appears in the article.: Navarrete-Muñoz EM; Vioque J; Toledo E; Oncina-Canovas A; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Alonso-Gómez ÁM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Bueno-Cavanillas A; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; de Cos Blanco AI; Ros E; Diez-Espino J; Babio N; Fernandez-Carrion R; Castañer O; Colom A; Compañ-Gabucio L; Lete IS; Crespo-Oliva E; Abete I; Tomaino L; Casas R; Fernandez-Garcia JC; Santos-Lozano JM; Sarasa I

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / Díaz López, Andres / Salas Salvadó, Jorge

Keywords: Stress Risk Prevalence Metabolic syndrome score Metaanalysis Insulin-resistance Homocysteine Folic-acid supplementation Folate Diseases Diabetes Cholesterol Cardiometabolic risk Association Adults folate diabetes cholesterol cardiometabolic risk

Abstract: © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.

Thematic Areas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14366207

Author's mail: andres.diaz@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat

Author identifier: 0000-0002-7500-5629 0000-0003-3527-5277 0000-0003-2700-7459

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://link.springer.com/article/10.1007/s00394-020-02364-4

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: European Journal Of Nutrition. 60 (2): 1125-1136

APA: Navarrete-Muñoz EM; Vioque J; Toledo E; Oncina-Canovas A; Martínez-González MÁ; Salas-Salvadó J; Corella D; Fitó M; Romaguera D; Alonso-Gómez ÁM; Wärn (2021). Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. European Journal Of Nutrition, 60(2), 1125-1136. DOI: 10.1007/s00394-020-02364-4

Article's DOI: 10.1007/s00394-020-02364-4

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications