Articles producció científica> Medicina i Cirurgia

Activation of nuclear factor-kappa B subunits c-Rel, p65 and p50 by plasma lipids and fatty acids across the menstrual cycle

  • Identification data

    Identifier: imarina:8263164
    Authors:
    Faustmann GTiran BTrajanoski SObermayer-Pietsch BGruber HJRibalta JRoob JMWinklhofer-Roob BM
    Abstract:
    © 2020 This study focused on a comprehensive analysis of the canonical activation pathway of the redox-sensitive transcription factor nuclear factor-kappa B (NF-κB) in peripheral blood mononuclear cells, addressing c-Rel, p65 and p50 activation in 28 women at early (T1) and late follicular (T2) and mid (T3) and late luteal (T4) phase of the menstrual cycle, and possible relations with fasting plasma lipids and fatty acids. For the first time, strong inverse relations of c-Rel with apolipoprotein B were observed across the cycle, while those with LDL cholesterol, triglycerides as well as saturated (SFA), particularly C14–C22 SFA, monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) clustered at T2. In contrast, p65 was positively related to LDL cholesterol and total n-6 PUFA, while p50 did not show any relations. C-Rel was not directly associated with estradiol and progesterone, but data suggested an indirect C22:5n-3-mediated effect of progesterone. Strong positive relations between estradiol and individual SFA, MUFA and n-3 PUFA at T1 were confined to C18 fatty acids; C18:3n-3 was differentially associated with estradiol (positively) and progesterone (inversely). Given specific roles of c-Rel activation in immune tolerance, inhibition of c-Rel activation by higher plasma apolipoprotein B and individual fatty acid concentrations could have clinical implications for female fertility.
  • Others:

    Author, as appears in the article.: Faustmann G; Tiran B; Trajanoski S; Obermayer-Pietsch B; Gruber HJ; Ribalta J; Roob JM; Winklhofer-Roob BM
    Department: Medicina i Cirurgia
    URV's Author/s: Ribalta Vives, Josep
    Keywords: Rela Peripheral blood mononuclear cells Pbmc P65 P50 Nuclear factor-kappa b Nf-κb N-6 fatty acids N-3 fatty acids Menstrual cycle Lipids Ldl-cholesterol Fatty acids Docosapentaenoic acid Cholesterol Canonical pathway C-rel Apolipoprotein b Apolipoprotein a-i Alpha-linolenic acid rela peripheral blood mononuclear cells pbmc p50 nuclear factor-kappa b nf-?b n-6 fatty acids n-3 fatty acids menstrual cycle lipids ldl-cholesterol fatty acids docosapentaenoic acid cholesterol canonical pathway c-rel apolipoprotein b apolipoprotein a-i alpha-linolenic acid
    Abstract: © 2020 This study focused on a comprehensive analysis of the canonical activation pathway of the redox-sensitive transcription factor nuclear factor-kappa B (NF-κB) in peripheral blood mononuclear cells, addressing c-Rel, p65 and p50 activation in 28 women at early (T1) and late follicular (T2) and mid (T3) and late luteal (T4) phase of the menstrual cycle, and possible relations with fasting plasma lipids and fatty acids. For the first time, strong inverse relations of c-Rel with apolipoprotein B were observed across the cycle, while those with LDL cholesterol, triglycerides as well as saturated (SFA), particularly C14–C22 SFA, monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) clustered at T2. In contrast, p65 was positively related to LDL cholesterol and total n-6 PUFA, while p50 did not show any relations. C-Rel was not directly associated with estradiol and progesterone, but data suggested an indirect C22:5n-3-mediated effect of progesterone. Strong positive relations between estradiol and individual SFA, MUFA and n-3 PUFA at T1 were confined to C18 fatty acids; C18:3n-3 was differentially associated with estradiol (positively) and progesterone (inversely). Given specific roles of c-Rel activation in immune tolerance, inhibition of c-Rel activation by higher plasma apolipoprotein B and individual fatty acid concentrations could have clinical implications for female fertility.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Psicología Physiology (medical) Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology & metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 08915849
    Author's mail: josep.ribalta@urv.cat
    Author identifier: 0000-0002-8879-4719
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0891584920312077?via%3Dihub
    Papper original source: Free Radical Biology And Medicine. 160 488-500
    APA: Faustmann G; Tiran B; Trajanoski S; Obermayer-Pietsch B; Gruber HJ; Ribalta J; Roob JM; Winklhofer-Roob BM (2020). Activation of nuclear factor-kappa B subunits c-Rel, p65 and p50 by plasma lipids and fatty acids across the menstrual cycle. Free Radical Biology And Medicine, 160(), 488-500. DOI: 10.1016/j.freeradbiomed.2020.08.012
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.freeradbiomed.2020.08.012
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Endocrinology & Metabolism,Physiology (Medical)
    Rela
    Peripheral blood mononuclear cells
    Pbmc
    P65
    P50
    Nuclear factor-kappa b
    Nf-κb
    N-6 fatty acids
    N-3 fatty acids
    Menstrual cycle
    Lipids
    Ldl-cholesterol
    Fatty acids
    Docosapentaenoic acid
    Cholesterol
    Canonical pathway
    C-rel
    Apolipoprotein b
    Apolipoprotein a-i
    Alpha-linolenic acid
    rela
    peripheral blood mononuclear cells
    pbmc
    p50
    nuclear factor-kappa b
    nf-?b
    n-6 fatty acids
    n-3 fatty acids
    menstrual cycle
    lipids
    ldl-cholesterol
    fatty acids
    docosapentaenoic acid
    cholesterol
    canonical pathway
    c-rel
    apolipoprotein b
    apolipoprotein a-i
    alpha-linolenic acid
    Zootecnia / recursos pesqueiros
    Química
    Psicología
    Physiology (medical)
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Endocrinology & metabolism
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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