Articles producció científica> Medicina i Cirurgia

Cost-effectiveness of direct oral anticoagulants versus vitamin K antagonist in atrial fibrillation: A study protocol using Real-World Data from Catalonia (FantasTIC Study)

  • Identification data

    Identifier: imarina:8505261
    Authors:
    Rojas, ZHLlorca, MRDMartín, CAGonçalves, AQCasajuana, MFernández-Sáez, JCumplido, DRDrago, EFCarrasco-Querol, NVilaubí, JMPAlegret, JM
    Abstract:
    BACKGROUND: Anticoagulant therapy is used for stroke prevention and proved to be effective and safe in the long term. The study aims to analyse the cost-effectiveness relationship of using of direct-acting oral anticoagulants vs vitamin K antagonists to prevent ischaemic stroke in patients with nonvalvular atrial fibrillation, including all the active ingredients marketed in Spain, prescribed for 2 years in the Primary Care service of the Institut Català de la Salut. METHODS: Population-based cohort study, in which the cost of the 2 treatment groups will be evaluated. Direct costs (pharmacy, primary care, emergency and hospitalization) and indirect costs (lost productivity) will be included from a social perspective. Effectiveness (assessed as the occurrence of a health event, the 1 of primary interest being stroke) will be determined, with a 2-year time horizon and a 3% discount rate. The average cost of the 2 groups of drugs will be compared using a regression model to determine the factors with the greatest influence on determining costs. We will carry out a univariate ('one-way') deterministic sensitivity analysis. DISCUSSION: We hope to provide relevant information about direct and indirect costs of oral anticoagulants, which, together with aspects of effectiveness and safety, could help shape the consensual decision-making of evaluating bodies.
  • Others:

    Author, as appears in the article.: Rojas, ZH; Llorca, MRD; Martín, CA; Gonçalves, AQ; Casajuana, M; Fernández-Sáez, J; Cumplido, DR; Drago, EF; Carrasco-Querol, N; Vilaubí, JMP; Alegret, JM
    Department: Medicina i Cirurgia
    URV's Author/s: Alegret Colomé, Josep Maria
    Keywords: Stroke prevention Primary health care Oral drug administration Management Guidelines Dabigatran Cost effectiveness Care Atrial fibrillation Anticoagulants
    Abstract: BACKGROUND: Anticoagulant therapy is used for stroke prevention and proved to be effective and safe in the long term. The study aims to analyse the cost-effectiveness relationship of using of direct-acting oral anticoagulants vs vitamin K antagonists to prevent ischaemic stroke in patients with nonvalvular atrial fibrillation, including all the active ingredients marketed in Spain, prescribed for 2 years in the Primary Care service of the Institut Català de la Salut. METHODS: Population-based cohort study, in which the cost of the 2 treatment groups will be evaluated. Direct costs (pharmacy, primary care, emergency and hospitalization) and indirect costs (lost productivity) will be included from a social perspective. Effectiveness (assessed as the occurrence of a health event, the 1 of primary interest being stroke) will be determined, with a 2-year time horizon and a 3% discount rate. The average cost of the 2 groups of drugs will be compared using a regression model to determine the factors with the greatest influence on determining costs. We will carry out a univariate ('one-way') deterministic sensitivity analysis. DISCUSSION: We hope to provide relevant information about direct and indirect costs of oral anticoagulants, which, together with aspects of effectiveness and safety, could help shape the consensual decision-making of evaluating bodies.
    Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Astronomia / física Antropologia / arqueologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josepmaria.alegret@urv.cat
    Author identifier: 0000-0002-6117-5512
    Record's date: 2024-02-11
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://journals.lww.com/md-journal/Fulltext/2020/09040/Cost_effectiveness_of_direct_oral_anticoagulants.79.aspx
    Papper original source: Medicine. 99 (36): e22054-
    APA: Rojas, ZH; Llorca, MRD; Martín, CA; Gonçalves, AQ; Casajuana, M; Fernández-Sáez, J; Cumplido, DR; Drago, EF; Carrasco-Querol, N; Vilaubí, JMP; Alegret (2020). Cost-effectiveness of direct oral anticoagulants versus vitamin K antagonist in atrial fibrillation: A study protocol using Real-World Data from Catalonia (FantasTIC Study). Medicine, 99(36), e22054-. DOI: 10.1097/MD.0000000000022054
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1097/MD.0000000000022054
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Stroke prevention
    Primary health care
    Oral drug administration
    Management
    Guidelines
    Dabigatran
    Cost effectiveness
    Care
    Atrial fibrillation
    Anticoagulants
    Saúde coletiva
    Odontología
    Nutrição
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geografía
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Astronomia / física
    Antropologia / arqueologia
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