Author, as appears in the article.: Hernández Rojas Z; Dalmau Llorca MR; Aguilar Martín C; Gonçalves AQ; Casajuana M; Fernández-Sáez J; Rodríguez Cumplido D; Forcadell Drago E; Carrasco-Querol N; Pepió Vilaubí JM; Alegret JM

Department: Medicina i Cirurgia

URV's Author/s: Alegret Colomé, Josep Maria

Keywords: Stroke prevention Primary health care Oral drug administration Management Guidelines Dabigatran Cost effectiveness Care Atrial fibrillation Anticoagulants

Abstract: BACKGROUND: Anticoagulant therapy is used for stroke prevention and proved to be effective and safe in the long term. The study aims to analyse the cost-effectiveness relationship of using of direct-acting oral anticoagulants vs vitamin K antagonists to prevent ischaemic stroke in patients with nonvalvular atrial fibrillation, including all the active ingredients marketed in Spain, prescribed for 2 years in the Primary Care service of the Institut Català de la Salut. METHODS: Population-based cohort study, in which the cost of the 2 treatment groups will be evaluated. Direct costs (pharmacy, primary care, emergency and hospitalization) and indirect costs (lost productivity) will be included from a social perspective. Effectiveness (assessed as the occurrence of a health event, the 1 of primary interest being stroke) will be determined, with a 2-year time horizon and a 3% discount rate. The average cost of the 2 groups of drugs will be compared using a regression model to determine the factors with the greatest influence on determining costs. We will carry out a univariate ('one-way') deterministic sensitivity analysis. DISCUSSION: We hope to provide relevant information about direct and indirect costs of oral anticoagulants, which, together with aspects of effectiveness and safety, could help shape the consensual decision-making of evaluating bodies.

Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Astronomia / física Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: josepmaria.alegret@urv.cat

Author identifier: 0000-0002-6117-5512

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.lww.com/md-journal/Fulltext/2020/09040/Cost_effectiveness_of_direct_oral_anticoagulants.79.aspx

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Medicine. 99 (36): e22054-

APA: Hernández Rojas Z; Dalmau Llorca MR; Aguilar Martín C; Gonçalves AQ; Casajuana M; Fernández-Sáez J; Rodríguez Cumplido D; Forcadell Drago E; Carrasco- (2020). Cost-effectiveness of direct oral anticoagulants versus vitamin K antagonist in atrial fibrillation: A study protocol using Real-World Data from Catalonia (FantasTIC Study). Medicine, 99(36), e22054-. DOI: 10.1097/MD.0000000000022054

Article's DOI: 10.1097/MD.0000000000022054

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications