Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

Author, as appears in the article.: Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, Maria; Xu, Yifan; Martinez-Gonzalez, Miguel A; Sayon-Orea, Carmen; Ruiz-Canela, Miguel; Toledo, Estefania; Martin Sanchez, Vicente; Estruch, Ramon; Maria Lamuela-Raventos, Rosa; Almanza-Aguilera, Enrique; Fito, Montserrat; Salas-Salvado, Jordi; Diaz-Lopez, Andres; Tinahones, Francisco J; Tur, Josep A; Romaguera, Dora; Konieczna, Jadwiga; Pinto, Xavier; Daimiel, Lidia; Rodriguez-Mateos, Ana; Alfredo Martinez, Jose

Department: Bioquímica i Biotecnologia

URV's Author/s: Díaz López, Andres / Salas Salvadó, Jorge

Keywords: Wine; Supplementation; Risk-factors; Risk; Resveratrol; Non-alcoholic fatty liver disease; Myocardium; Models, statistical; Middle aged; Metabolic syndrome; Mediterranean diet adherence; Male; Liver enzymes; Liver; Insulin sensitivity; Inflammation; Humans; Homeostasis model assessment; Health; Female; Fatty liver; Disease; Cross-sectional studies; Biomarkers; Bioavailability; Antioxidant; Aged

Abstract: Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvención con DIeta MEDiterránea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (µ-SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (?T3= -0.15, 95% CI; -0.28, -0.02, p-trend = 0.030), VLDL-c, (?T3= -4.21, 95% CI; -7.97, -0.46, p-trend = 0.039), total cholesterol/HDL ratio Moreover, (?T3= -0.35, 95% CI; -0.66, -0.03, p-trend = 0.241). For liver enzymes: log AST (?T3= -0.12, 95% CI; -0.22, -0.02, p-trend = 0.011, and log GGT (?T3= -0.24, 95% CI; -0.42, -0.06, p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD.

Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Physical and theoretical chemistry; Pharmaceutical science; Organic chemistry; Odontología; Nutrição; Molecular medicine; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Geografía; General medicine; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Educação física; Economia; Drug discovery; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, organic; Chemistry, multidisciplinary; Chemistry (miscellaneous); Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física; Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14203049

Author's mail: andres.diaz@urv.cat; jordi.salas@urv.cat

Record's date: 2025-02-19

Paper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1420-3049/25/18/4340

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Molecules. 25 (18): 4340-

APA: Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, Maria; Xu, Yifan; Martinez-Gonzalez, Miguel A; Sayon-Orea, Carmen; Ruiz-Canela, Miguel; Toledo, Es (2020). Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome. Molecules, 25(18), 4340-. DOI: 10.3390/molecules25184340

Article's DOI: 10.3390/molecules25184340

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications