Author, as appears in the article.: Domagalski JT; Xifre-Perez E; Tabrizi MA; Ferre-Borrull J; Marsal LF
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Ferré Borrull, José / Marsal Garví, Luis Francisco / Xifré Pérez, Elisabet
Project code: Grant agreement No. 713679
Keywords: Stimuli-responsive release Self-assembly Magnetic properties Cathepsin b Anodic alumina nanotubes
Abstract: © 2020 Elsevier Inc. In this work, we present the process to provide anodic alumina nanotubes with magnetic responsivity based on magnetic nanoparticles. We demonstrate the possibility to cause the motion of these composite nanotubes under magnetic field, providing them with guided mobility. The obtained magnetic anodic alumina nanotubes are completely characterized and their potential to undergo selective and effective functionalization, and stimuli-responsive load release is demonstrated. For this purpose, protease-triggered release of fluorescent molecules loaded inside the magnetic anodic alumina nanotubes (MAANTs) by selective functionalization is performed. The inner walls of the MAANTs were selectively covered with protein padding of albumin-fluorescein isothiocyanate conjugate (FITC-BSA) through means of silanization. Protein functionalization was designed to undergo proteolytic hydrolysis in presence of cathepsin B- protease highly expressed during growth and initial stages of tumor metastasis – in order to cleave peptide bond of albumin and release fluorescent fragments of the protein. Proteolytic reaction with the enzyme is performed under acidic conditions. Presented arrangement is an exemplary combination of functionalities – which are vast – and of value for applications like drug delivery and biosensing applications.
Thematic Areas: Surfaces, coatings and films Química Nutrição Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Electronic, optical and magnetic materials Economia Colloid and surface chemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, physical Biotecnología Biomaterials Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lluis.marsal@urv.cat elisabet.xifre@urv.cat josep.ferre@urv.cat
Author identifier: 0000-0002-5976-1408 0000-0001-6072-9889 0000-0002-5210-5133
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0021979720312984?via%3Dihub
Funding program: Marti i Franquès COFUND Doctoral Programme
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Colloid And Interface Science. 584 236-245
APA: Domagalski JT; Xifre-Perez E; Tabrizi MA; Ferre-Borrull J; Marsal LF (2021). Magnetic nanoparticle decorated anodic alumina nanotubes for fluorescent detection of cathepsin B. Journal Of Colloid And Interface Science, 584(), 236-245. DOI: 10.1016/j.jcis.2020.09.109
Acronym: MFP
Article's DOI: 10.1016/j.jcis.2020.09.109
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Funding program action: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
Publication Type: Journal Publications
Repositori URV