Author, as appears in the article.: Gutierrez-Marin, Desiree; Escribano, Joaquin; Closa-Monasterolo, Ricardo; Ferre, Natalia; Venables, Michelle; Singh, Priya; Wells, Jonathan C K; Munoz-Hernando, Judit; Zaragoza-Jordana, Marta; Gispert-Llaurado, Mariona; Rubio-Torrents, Carmen; Alcazar, Mireia; Nunez-Roig, Merce; Monne-Gelonch, Raquel; Feliu, Albert; Basora, Josep; Alejos, Ana M; Luque, Veronica
Department: Medicina i Cirurgia
URV's Author/s: Alcázar López, Mireia / Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Feliu Rovira, Albert / Ferre Pallas, Natalia / Gispert Llauradó, Mariona / GUTIÉRREZ MARÍN, DESIRÉE / Luque Moreno, Verònica / Muñoz Hernando, Judit / RUBIO TORRENTS, MARÍA DEL CARMEN / Zaragoza Jordana, Marta
Keywords: Validation study Statistical bias Sex difference Reproducibility of results Reproducibility Randomized controlled trials as topic Randomized controlled trial (topic) Procedures Plethysmography Pediatric obesity Obesity Measurement precision Measurement accuracy Male Humans Human Female Fat free mass Diagnostic imaging Density Cross-sectional study Cross-sectional studies Controlled study Comparative study Cluster analysis Clinical feature Clinical assessment Children Childhood obesity Child Body mass index Body mass Body composition Bias Article Anthropometry Air displacement plethysmography Age Adolescent Adipose tissue
Abstract: Background & aimsAssessment of Fat Mass (FM) and fat-free mass (FFM) using Air-displacement plethysmography (ADP) technique assumes constant density of FFM (D<sub>FFM</sub>) by age and sex. It has been recently shown that D<sub>FFM</sub> further varies according to body mass index (BMI), meaning that ADP body composition assessments of children with obesity could be biased if D<sub>FFM</sub> is assumed to be constant. The aim of this study was to validate the use of the calculations of D<sub>FFM</sub> (rather than constant density of the FFM) to improve accuracy of body composition assessment in children with obesity.Methodscross-sectional validation study in 66 children with obesity (aged 8-14 years) where ADP assessments of body composition assuming constant density (FFM<sub>BODPOD</sub> and FM<sub>BODPOD)</sub> were compared to those where D<sub>FFM</sub> was adjusted in relation to BMI (FFM<sub>adjusted</sub> and FM<sub>adjusted</sub>), and both compared to the gold standard reference, the 4-component model (FFM<sub>4C</sub> and FM<sub>4C</sub>).ResultsFFM<sub>BODPOD</sub> was overestimated by 1.50 kg (95%CI -0.68 kg, 3.63 kg) while FFM<sub>adjusted</sub> was 0.71 kg (-1.08 kg, 2.51 kg) (percentage differences compared to FFM<sub>4C</sub> were 4.9% (±2.9%) and 2.8% (±2.1%), respectively (p < 0.001)). Consistently, FM was underestimated by both methods, representing a mean difference between methods of 4.0% (±2.9%) and 6.8% (±3.8%), respectively, when compared to the reference method. The agreement and reliability of body composition assessments were improved when adjusted using calculations (adjusted models) rather than assuming constant D<sub>FFM</sub>.ConclusionsThe use of constant values for fat-free mass properties may increase bias when assessing body composition (FM and FFM) in children with obesity by two-component techniques such as ADP. Using adjusted corrections as proposed in the present work may reduce the bias by half.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.luque@urv.cat mariona.gispert@urv.cat mariona.gispert@urv.cat marta.zaragoza@urv.cat marta.zaragoza@urv.cat albert.feliu@urv.cat judit.munoz@urv.cat judit.munoz@urv.cat judit.munoz@urv.cat ricardo.closa@urv.cat mireia.alcazar@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
Author identifier: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0001-9813-4645 0000-0002-2838-1525 0000-0002-5041-459X
Record's date: 2024-09-21
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30362-9/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Nutrition. 40 (3): 1102-1107
APA: Gutierrez-Marin, Desiree; Escribano, Joaquin; Closa-Monasterolo, Ricardo; Ferre, Natalia; Venables, Michelle; Singh, Priya; Wells, Jonathan C K; Munoz (2021). A novel approach to assess body composition in children with obesity from density of the fat-free mass. Clinical Nutrition, 40(3), 1102-1107. DOI: 10.1016/j.clnu.2020.07.011
Article's DOI: 10.1016/j.clnu.2020.07.011
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV