Author, as appears in the article.: Pascual-Caro S; Borrull F; Aguilar C; Calull M

Department: Química Analítica i Química Orgànica

e-ISSN: 2297-8739

URV's Author/s: Aguilar Anguera, Maria del Carmen / Borrull Ballarín, Francesc / Calull Blanch, Marta / Pascual Caro, Sergi

Keywords: Triple-quadrupole Tandem mass spectrometry Synthetic cathinones Stimulants Solid-phase extraction Quantification Performance Orbitrap Metabolites High-resolution mass spectrometry Hair Designer drugs Biological samples Bioanalysis Abuse

Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration levels. In general, liquid chromatography mass spectrometry detection plays an important role in these methods and the trend is to use low-resolution and high-resolution mass spectrometry. In this article, for the first time, we compare these two analyzers using an Orbitrap and a triple quadrupole mass spectrometer in order to determine a group of synthetic cathinones in urine and oral fluid samples. For this comparison, we evaluated and compared different parameters: Method detection and quantification limits, linearity, apparent recoveries, matrix effect, repeatability (intra-day), reproducibility (inter-day), and accuracy. Similar results were obtained for the two analyzers for the apparent recoveries and matrix effect. However, triple quadrupole showed higher sensitivity compared to Orbitrap for both urine and oral fluid samples. The quantification limits in urine and the detection limits in saliva were two times lower for triple quadrupole. Finally, when blind samples were analyzed to study the accuracy, similar results were obtained for both analyzers.

Thematic Areas: Filtration and separation Chemistry, analytical Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: francesc.borrull@urv.cat marta.calull@urv.cat carme.aguilar@urv.cat sergi.pascual@estudiants.urv.cat

Author identifier: 0000-0003-2718-9336 0000-0002-5258-1949 0000-0002-5913-2599 0000-0001-8890-5100

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2297-8739/7/4/53

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Separations. 7 (4): 1-14

APA: Pascual-Caro S; Borrull F; Aguilar C; Calull M (2020). Determination of synthetic cathinones in urine and oral fluid by liquid chromatography high-resolution mass spectrometry and low-resolution mass spectrometry: A method comparison. Separations, 7(4), 1-14. DOI: 10.3390/separations7040053

Article's DOI: 10.3390/separations7040053

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications