Author, as appears in the article.: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A

Department: Enginyeria Química

URV's Author/s: Tylkowski, Bartosz

Keywords: Size Nanosheets In-vitro Graphene oxide Drug modification Delivery Carrier Carbon-based materials Anticancer drug Accumulation

Abstract: © 2020 by the authors. Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.

Thematic Areas: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: bartosz.tylkowski@urv.cat

Author identifier: 0000-0002-4163-0178

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1996-1944/13/19/4224

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Materials. 13 (19):

APA: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A (2020). Ciprofloxacin and graphene oxide combination-New face of a known drug. Materials, 13(19), -. DOI: 10.3390/MA13194224

Article's DOI: 10.3390/MA13194224

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications