Articles producció científica> Bioquímica i Biotecnologia

Sperm DNA methylation changes after short-term nut supplementation in healthy men consuming a Western-style diet

  • Identification data

    Identifier: imarina:9047992
    Authors:
    Salas-Huetos, AlbertJames, Emma RSalas-Salvado, JordiBullo, MonicaAston, Kenneth ICarrell, Douglas TJenkins, Timothy G
    Abstract:
    Background Many environmental and lifestyle factors have been implicated in the decline of sperm quality, with diet being one of the most plausible factors identified in recent years. Moreover, several studies have reported a close association between the alteration of specific sperm DNA methylation signatures and semen quality. Objectives To evaluate the effect of tree nut consumption on sperm DNA methylation patterns in healthy individuals reporting eating a Western-style diet. Material and methods This is a post hoc analysis conducted in a subset of participants (healthy, non-smoking, and young) from the FERTINUTS 14-wk randomized-controlled, parallel trial, recruited between December 2015 and February 2017. The participants included in the current study (n = 72) were randomly selected in a proportion 2:1 from the original FERTINUTS trial between the 98 participants that completed the entire dietary intervention (nut group, n = 48; control group, n = 24). Sperm DNA methylation patterns were examined at baseline and after 14 weeks in 48 individuals consuming 60 g/d of mixed nuts (nut group) and in 24 individuals following the usual Western-style diet avoiding consumption of nuts (control group). Results Over the course of the trial, no significant changes in global methylation were observed between groups. However, in the nut group, we identified 36 genomic regions that were significantly differentially methylated between the baseline and the end of the trial and 97.2% of the regions displayed hypermethylation. We identified no such change in the control group over the same period of time. We also utilized the recently developed germ line age calculator to determine if nut consumption resulted in alterations to the epigenetic age of cells and no significant difference
  • Others:

    Author, as appears in the article.: Salas-Huetos, Albert; James, Emma R; Salas-Salvado, Jordi; Bullo, Monica; Aston, Kenneth I; Carrell, Douglas T; Jenkins, Timothy G
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Salas Huetos, Albert / Salas Salvadó, Jorge
    Keywords: Young adult Spermatozoa Sperm dna methylation Semen quality Semen analysis Nuts Methylome Male Humans Healthy volunteers Healthy individuals Genes Epigenetics Dna methylation Dietary supplements Diet, western Diet Cancer Array Adult
    Abstract: Background Many environmental and lifestyle factors have been implicated in the decline of sperm quality, with diet being one of the most plausible factors identified in recent years. Moreover, several studies have reported a close association between the alteration of specific sperm DNA methylation signatures and semen quality. Objectives To evaluate the effect of tree nut consumption on sperm DNA methylation patterns in healthy individuals reporting eating a Western-style diet. Material and methods This is a post hoc analysis conducted in a subset of participants (healthy, non-smoking, and young) from the FERTINUTS 14-wk randomized-controlled, parallel trial, recruited between December 2015 and February 2017. The participants included in the current study (n = 72) were randomly selected in a proportion 2:1 from the original FERTINUTS trial between the 98 participants that completed the entire dietary intervention (nut group, n = 48; control group, n = 24). Sperm DNA methylation patterns were examined at baseline and after 14 weeks in 48 individuals consuming 60 g/d of mixed nuts (nut group) and in 24 individuals following the usual Western-style diet avoiding consumption of nuts (control group). Results Over the course of the trial, no significant changes in global methylation were observed between groups. However, in the nut group, we identified 36 genomic regions that were significantly differentially methylated between the baseline and the end of the trial and 97.2% of the regions displayed hypermethylation. We identified no such change in the control group over the same period of time. We also utilized the recently developed germ line age calculator to determine if nut consumption resulted in alterations to the epigenetic age of cells and no significant differences were found. Discussion and conclusion Adding nuts to a regular Western-style diet subtly impacts sperm DNA methylation in specific regions, demonstrating that there are some sperm epigenome regions that could respond to diet.
    Thematic Areas: Zootecnia / recursos pesqueiros Urology Reproductive medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Andrology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: albert.salas@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0001-5914-6862 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1111/andr.12911
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Andrology. 9 (1): 260-268
    APA: Salas-Huetos, Albert; James, Emma R; Salas-Salvado, Jordi; Bullo, Monica; Aston, Kenneth I; Carrell, Douglas T; Jenkins, Timothy G (2021). Sperm DNA methylation changes after short-term nut supplementation in healthy men consuming a Western-style diet. Andrology, 9(1), 260-268. DOI: 10.1111/andr.12911
    Article's DOI: 10.1111/andr.12911
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Andrology,Endocrinology,Endocrinology, Diabetes and Metabolism,Reproductive Medicine,Urology
    Young adult
    Spermatozoa
    Sperm dna methylation
    Semen quality
    Semen analysis
    Nuts
    Methylome
    Male
    Humans
    Healthy volunteers
    Healthy individuals
    Genes
    Epigenetics
    Dna methylation
    Dietary supplements
    Diet, western
    Diet
    Cancer
    Array
    Adult
    Zootecnia / recursos pesqueiros
    Urology
    Reproductive medicine
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
    Andrology
  • Documents:

  • Cerca a google

    Search to google scholar