Articles producció científica> Bioquímica i Biotecnologia

Large gene overlaps in prokaryotic genomes: result of functional constraints or mispredictions?

  • Identification data

    Identifier: imarina:9048004
    Handle: https://hdl.handle.net/20.500.11797/imarina9048004
    Authors:
    Abstract:
    Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.

  • Others:

    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-335
    Department: Bioquímica i Biotecnologia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    URV's Author/s: Pallejà, Albert; D Harrington, Eoghan; Bork, Peer
    Article's DOI: 10.1186/1471-2164-9-335
    Abstract: Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.
    Journal publication year: 2008
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Record's date: 2021-02-05
    Journal volume: 9