Author, as appears in the article.: Pallares-Carratala, Vicente; Quesada, Jose A.; Orozco-Beltran, Domingo; Amigo-Grau, Nuria; Lopez-Pineda, Adriana; Fernandez Gimenez, Antonio; Gil-Guillen, Vicente F.; Correig, Xavier; Masana, Lluis; Monleon, Daniel; Redon, Josep; Pascual, Reyes; Carratala-Munuera, Concepcion;

Department: Medicina i Cirurgia Enginyeria Electrònica, Elèctrica i Automàtica

URV's Author/s: Correig Blanchar, Francesc Xavier / Masana Marín, Luis

Keywords: Spectroscopy Risk Predictors Particle number Lipids Density-lipoprotein cholesterol Cardiovascular-disease Association

Abstract: Background and aim Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL-C and HDL-C, but with alterations in the number and size of lipoprotein particles (as measured by nuclear magnetic resonance [NMR]) and to analyse their sociodemographic, clinical and biochemical characteristics. Methods Cross-sectional study in occupational risks prevention centre in Castellon (Spain) in 2017 and 2018, in consecutively recruited adults (18-65 years) with no known CVD. Sociodemographic, clinical and biochemical variables were collected. Lipid profiles were analysed (Liposcale test), along with the concentration, size and number of the main types of lipoprotein particles, determined by 2D diffusion-ordered NMR spectroscopy. Using contingency tables, we analysed the characteristics of people with normal LDL and HDL cholesterol but abnormal levels of LDL and HDL particles. The magnitude of association between explanatory variables and abnormal levels of each kind of lipoprotein was assessed with multivariable logistic regression models. Results Of the 400 total participants (31.3% women; age 46.4 +/- 4.3 years), 169 had normal LDL and HDL cholesterol. Abnormal lipoprotein particle values depended on the subtype: prevalence of abnormal LDL levels ranged from 8.3% to 36.7%; and of HDL, from 28.4% to 42.6%. High systolic blood pressure and total cholesterol were significantly associated with abnormal LDL levels. Male sex and high systolic blood pressure were associated with abnormalities in HDL. Conclusions An extended lipids profile, obtained by NMR, enables the identification of people with normal HDL-C and LDL-C levels who present abnormal levels of LDL-P and/or HDL-P. Higher total cholesterol, systolic blood pressure, BMI and male sex were significantly associated with these abnormal values.

Thematic Areas: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas ii

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: xavier.correig@urv.cat luis.masana@urv.cat

Author identifier: 0000-0002-6902-3054 0000-0002-0789-4954

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijcp.13610

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Clinical Practice. 75 (e13610): e13610-

APA: Pallares-Carratala, Vicente; Quesada, Jose A.; Orozco-Beltran, Domingo; Amigo-Grau, Nuria; Lopez-Pineda, Adriana; Fernandez Gimenez, Antonio; Gil-Guil (2021). Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: The LipoLab Study. International Journal Of Clinical Practice, 75(e13610), e13610-. DOI: 10.1111/ijcp.13610

Article's DOI: 10.1111/ijcp.13610

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications