Articles producció científica> Medicina i Cirurgia

Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

  • Identification data

    Identifier: imarina:9060862
    Authors:
    Ejarque, MiriamSabadell-Basallote, JoanBeiroa, DanielCalvo, EnriqueKeiran, NoeliaNunez-Roa, CatalinaRodriguez, Maria del MarSabench, Fatimadel Castillo, DanielJimenez, VeronicaBosch, FatimaNogueiras, RubenVendrell, JoanFernandez-Veledo, Sonia
    Abstract:
    Background and Purpose Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to nutritional intake that exerts a wide range of effects by activating GLP-2 receptors. In addition to its intestinotrophic effects, GLP-2 also positively influences glucose metabolism under conditions of obesity, but the mechanisms behind this remain unclear. Here, we have investigated the molecular role of the GLP-2/GLP-2 receptor axis in energetic metabolism, focusing on its potential modulatory effects on adipose tissue. Experimental Approach Physiological measurements (body weight, food intake, locomotor activity, and energy expenditure) and metabolic studies (glucose and insulin tolerance tests) were performed on lean and obese mice treated with the protease-resistant GLP-2 analogue teduglutide. Key Results Acute but not chronic centrally administered teduglutide decreased food intake and weight-gain. By contrast, chronic activation of peripheral GLP-2 receptors increased body weight-independent glucose tolerance and had anti-inflammatory effects on visceral adipose tissue. Using a gene silencing approach, we found that adipose tissue is necessary for these beneficial effects of teduglutide. Finally, teduglutide regulates the inflammatory state and acts as an anabolic signal in human adipocytes. Conclusion and Implications Overall, our data identify adipose tissue as a new, clinically relevant, site of action for GLP-2 activity in obesity.
  • Others:

    Author, as appears in the article.: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fatima; del Castillo, Daniel; Jimenez, Veronica; Bosch, Fatima; Nogueiras, Ruben; Vendrell, Joan; Fernandez-Veledo, Sonia;
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Calvo Manso, Enrique / Del Castillo Déjardin, Daniel / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Sabench Pereferrer, Fàtima / Vendrell Ortega, Juan José
    Keywords: Teduglutide Short-bowel syndrome Protein-coupled receptor Pharmacology Obesity Obese mice Nervous-system Inflammatory Inflammation In-vivo Glucagon-like peptide-2 Glp‐ Glp-2 Concise guide Anti‐ Anti-inflammatory Adipose tissue 2
    Abstract: Background and Purpose Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to nutritional intake that exerts a wide range of effects by activating GLP-2 receptors. In addition to its intestinotrophic effects, GLP-2 also positively influences glucose metabolism under conditions of obesity, but the mechanisms behind this remain unclear. Here, we have investigated the molecular role of the GLP-2/GLP-2 receptor axis in energetic metabolism, focusing on its potential modulatory effects on adipose tissue. Experimental Approach Physiological measurements (body weight, food intake, locomotor activity, and energy expenditure) and metabolic studies (glucose and insulin tolerance tests) were performed on lean and obese mice treated with the protease-resistant GLP-2 analogue teduglutide. Key Results Acute but not chronic centrally administered teduglutide decreased food intake and weight-gain. By contrast, chronic activation of peripheral GLP-2 receptors increased body weight-independent glucose tolerance and had anti-inflammatory effects on visceral adipose tissue. Using a gene silencing approach, we found that adipose tissue is necessary for these beneficial effects of teduglutide. Finally, teduglutide regulates the inflammatory state and acts as an anabolic signal in human adipocytes. Conclusion and Implications Overall, our data identify adipose tissue as a new, clinically relevant, site of action for GLP-2 activity in obesity.
    Thematic Areas: Saúde coletiva Química Psicología Pharmacology & pharmacy Pharmacology Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    Author's mail: sonia.fernandez@urv.cat enrique.calvo@urv.cat danieldel.castillo@urv.cat fatima.sabench@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0003-0456-3102 0000-0001-7024-7824 0000-0002-9262-8756 0000-0002-6994-6115
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15278
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: British Journal Of Pharmacology. 178 (10): 2131-2145
    APA: Ejarque, Miriam; Sabadell-Basallote, Joan; Beiroa, Daniel; Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Rodriguez, Maria del Mar; Sabench, Fat (2021). Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function. British Journal Of Pharmacology, 178(10), 2131-2145. DOI: 10.1111/bph.15278
    Article's DOI: 10.1111/bph.15278
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Pharmacology,Pharmacology & Pharmacy
    Teduglutide
    Short-bowel syndrome
    Protein-coupled receptor
    Pharmacology
    Obesity
    Obese mice
    Nervous-system
    Inflammatory
    Inflammation
    In-vivo
    Glucagon-like peptide-2
    Glp‐ Glp-2
    Concise guide
    Anti‐ Anti-inflammatory
    Adipose tissue
    2
    Saúde coletiva
    Química
    Psicología
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
  • Documents:

  • Cerca a google

    Search to google scholar