Author, as appears in the article.: Companys, Judit; Pla-Paga, Laura; Calderon-Perez, Lorena; Llaurado, Elisabet; Sola, Rosa; Pedret, Anna; Valls, Rosa M.;

Department: Medicina i Cirurgia

URV's Author/s: Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria

Keywords: Yogurt consumption Visceral fat accumulation Type-2 diabetes-mellitus Type 2 diabetes Probiotics Obesity Metabolic syndrome Lipid profile Lactobacillus-gasseri sbt2055 Hypercholesterolemia Glycemic control Fermented dairy Double-blind Cardiometabolic disease Body-mass index Blood mononuclear-cells

Abstract: Fermented dairy foods (FDFs) and probiotics are promising tools for the prevention and management of cardiometabolic diseases (CMDs), respectively. The relation between the regular consumption of FDFs and CMD risk factors was assessed by prospective cohort studies (PCSs), and the effect of probiotic supplementation added into a dairy matrix on CMD parameters was evaluated by randomized controlled trials (RCTs). Moreover, the effects of probiotic supplementation added into a dairy matrix were compared with those administered in capsule/powder form. Twenty PCSs and 52 RCTs met the inclusion criteria for the systematic review and meta-analysis. In PCSs, fermented milk was associated with a 4% reduction in risk of stroke, ischemic heart disease, and cardiovascular mortality [RR (95% CI); 0.96 (0.94, 0.98)]; yogurt intake was associated with a risk reduction of 27% [RR (95% CI); 0.73 (0.70, 0.76)] for type 2 diabetes (T2D) and 20% [RR (95% CI); 0.80 (0.74, 0.87)] for metabolic syndrome development. In RCTs, probiotic supplementation added into dairy matrices produced a greater reduction in lipid biomarkers than when added into capsules/powder in hypercholesterolemic subjects, and probiotic supplementation by capsules/powder produced a greater reduction in T2D biomarkers than when added into dairy matrices in diabetic subjects. Both treatments (dairy matrix and capsules/powder) resulted in a significant reduction in anthropometric parameters in obese subjects. In summary, fermented milk consumption is associated with reduced cardiovascular risk, while yogurt intake is associated with a reduced risk of T2D and metabolic syndrome development in the general population. Furthermore, probiotic supplementation added into dairy matrices could be considered beneficial for lowering lipid concentrations and reducing anthropometric parameters. Additionally, probiotic capsule/powder supplementation could contribute to T2D management and reduce anthropometric parameters. However, these results should be interpreted with caution due to the heterogeneity of the studies and the different probiotic strains used in the studies.

Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina ii Food science Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: judit.companys@urv.cat lorena.calderon@urv.cat elisabet.llaurado@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat lorena.calderon@urv.cat judit.companys@urv.cat judit.companys@urv.cat

Author identifier: 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-7439-9531 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942 0000-0003-0766-0733 0000-0003-1485-0818 0000-0003-1485-0818

Record's date: 2023-02-27

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://academic.oup.com/advances/article-abstract/11/4/834/5819130?redirectedFrom=fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Advances In Nutrition. 11 (4): 834-863

APA: Companys, Judit; Pla-Paga, Laura; Calderon-Perez, Lorena; Llaurado, Elisabet; Sola, Rosa; Pedret, Anna; Valls, Rosa M.; (2020). Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis. Advances In Nutrition, 11(4), 834-863. DOI: 10.1093/advances/nmaa030

Article's DOI: 10.1093/advances/nmaa030

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications