Author, as appears in the article.: Yeregui E; Viladés C; Domingo P; Ceausu A; Pacheco YM; Veloso S; Inciarte A; Vidal-González J; Peraire M; Perpiñán C; Falcó V; Masip J; Alba V; Vargas M; Martí A; Reverté L; Mallolas J; Vidal F; Peraire J; Rull A
Department: Medicina i Cirurgia
e-ISSN: 2352-3964
URV's Author/s: Ceausu, Andra / Martí Zaragoza, Àlex / Masip Morcillo, Jenifer / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Veloso Esteban, Sergio / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria / Yeregui Etxeberria, Elena
Keywords: Poor immune recovery Polymorphisms variants Hiv Chemokines Chemokine receptors Antiretroviral therapy receptors poor immune recovery polymorphisms variants infection hiv genotype cxcr4 chemokines chemokine receptors
Abstract: © 2020 The Authors Background: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T-cell turnover. Methods: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery. Findings: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (Δ32) determine the baseline plasma RANTES and MIP-α concentrations, respectively, in participants with poor immune response. Interpretation: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance. Funding: This work was supported by Fondo de Investigacion Sanitaria and SPANISH AIDS Research Network (ISCIII-FEDER); AGAUR and Gilead Fellowship. FV and YMP are supported by grants from the Programa de Intensificación (ISCIII) and Servicio Andaluz de Salud, respectively. JVG,EY and LR are supported by the Instituto de Salud Carlos III (ISCIII). AR is supported by Departament de Salut, Generalitat de Catalunya and by the Instituto de Salud Carlos III (ISCIII).
Thematic Areas: Saúde coletiva Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i General medicine General biochemistry,genetics and molecular biology Ciências biológicas ii Biotecnología Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andra.ceausu@urv.cat sergio.veloso@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat elena.yeregui@estudiants.urv.cat alex.marti@estudiants.urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat francesc.vidal@urv.cat
Author identifier: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186
Record's date: 2024-07-27
Journal volume: 62
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30453-9/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Ebiomedicine. 62 (103077): 103077-
APA: Yeregui E; Viladés C; Domingo P; Ceausu A; Pacheco YM; Veloso S; Inciarte A; Vidal-González J; Peraire M; Perpiñán C; Falcó V; Masip J; Alba V; Vargas (2020). High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients. Ebiomedicine, 62(103077), 103077-. DOI: 10.1016/j.ebiom.2020.103077
Article's DOI: 10.1016/j.ebiom.2020.103077
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV