Articles producció científica> Bioquímica i Biotecnologia

Association between serum vitamin B12 and global dna methylation in colorectal cancer patients

  • Identification data

    Identifier: imarina:9138899
    Handle: http://hdl.handle.net/20.500.11797/imarina9138899
  • Authors:

    Boughanem H
    Hernandez-Alonso P
    Tinahones A
    Babio N
    Salas-Salvadó J
    Tinahones FJ
    Macias-Gonzalez M
  • Others:

    Author, as appears in the article.: Boughanem H; Hernandez-Alonso P; Tinahones A; Babio N; Salas-Salvadó J; Tinahones FJ; Macias-Gonzalez M
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Keywords: Vitamin b12 Line1 Dna methylation Colorectal cancer
    Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin B12 has been widely related to methionine metabolism, which is an essential component for biological methylation reactions, including DNA methylation. However, the relationship between vitamin B12 and DNA methylation is still controversial. In addition, there is increasing evidence for the association between vitamin B12 and the risk of colorectal cancer (CRC), although results of this association need to be assessed with caution. For this purpose, we hypothesized that serum vitamin B12 could be associated with global DNA methylation in the CRC context. To test this hypothesis, we studied the association between global DNA methylation through long interspersed nuclear element-1 (LINE1) in CRC patients under the 25th percentile of serum vitamin B12. We found that the high vitamin B12 group had low LINE1 methylation in both tumor area and peripheral blood mononuclear cells (PBMCs) than the low serum vitamin B12 group. LINE1 methylation levels were significantly lower in tumor area compared to the adjacent tumor-free area, only in the high vitamin B12 group. LINE1 methylation in visceral adipose tissue (VAT) and PBMCs were correlated with tumoral, inflammatory, and insulin metabolism markers. However, the interaction between LINE1 methylation and vitamin B12 levels was associated with neoadjuvant therapy in the regression analysis only in men, suggesting a beneficial relationship. In conclusion, our results reported an inverse association between DNA methylation and vitamin B12 in the CRC context, which suggests that vitamin B12 may be implicated in an epigenetic state or mediation in CRC.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nancy.babio@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0003-3527-5277 0000-0003-2700-7459
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/12/11/3567
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 12 (11): 1-12
    APA: Boughanem H; Hernandez-Alonso P; Tinahones A; Babio N; Salas-Salvadó J; Tinahones FJ; Macias-Gonzalez M (2020). Association between serum vitamin B12 and global dna methylation in colorectal cancer patients. Nutrients, 12(11), 1-12. DOI: 10.3390/nu12113567
    Article's DOI: 10.3390/nu12113567
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Vitamin b12
    Line1
    Dna methylation
    Colorectal cancer
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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