Articles producció científica> Bioquímica i Biotecnologia

A ten-day grape seed procyanidin treatment prevents certain ageing processes in female rats over the long term

  • Identification data

    Identifier: imarina:9138948
    Authors:
    Grau-Bove, CarmeSierra-Cruz, MartaMiguens-Gomez, AlbaRodriguez-Gallego, EstherBeltran-Debon, RaulBlay, MayteTerra, XimenaPinent, MontserratArdevol, Anna
    Abstract:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.
  • Others:

    Author, as appears in the article.: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montserrat; Ardevol, Anna
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Grau Bové, Maria Carmen / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
    Keywords: Tumor Time factors Rats, wistar Rats Procyanidins Proanthocyanidins Grape seed proanthocyanidins Grape seed extract Glucagon/insulin Food intake Female Drug administration schedule Body weight Body composition Animals Aging Ageing Adiposity
    Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/12/12/3647
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 12 (12): 1-12
    APA: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montser (2020). A ten-day grape seed procyanidin treatment prevents certain ageing processes in female rats over the long term. Nutrients, 12(12), 1-12. DOI: 10.3390/nu12123647
    Article's DOI: 10.3390/nu12123647
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Tumor
    Time factors
    Rats, wistar
    Rats
    Procyanidins
    Proanthocyanidins
    Grape seed proanthocyanidins
    Grape seed extract
    Glucagon/insulin
    Food intake
    Female
    Drug administration schedule
    Body weight
    Body composition
    Animals
    Aging
    Ageing
    Adiposity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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