Articles producció científica> Bioquímica i Biotecnologia

Modulation of food intake by differential TAS2R stimulation in rat

  • Identification data

    Identifier: imarina:9138970
    Authors:
    Grau-Bove, CarmeMiguens-Gomez, AlbaGonzalez-Quilen, CarlosFernandez-Lopez, Jose-AntonioRemesar, XavierTorres-Fuentes, CristinaAvila-Roman, JavierRodriguez-Gallego, EstherBeltran-Debon, RaulTeresa Blay, MTerra, XimenaArdevol, AnnaPinent, Montserrat
    Abstract:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats.
  • Others:

    Author, as appears in the article.: Grau-Bove, Carme; Miguens-Gomez, Alba; Gonzalez-Quilen, Carlos; Fernandez-Lopez, Jose-Antonio; Remesar, Xavier; Torres-Fuentes, Cristina; Avila-Roman, Javier; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Teresa Blay, M; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Ávila Román, Francisco Javier / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Grau Bové, Maria Carmen / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena / Torres Fuentes, Cristina
    Keywords: Taste receptors, type 2 Taste Tas2r5 Tas2r39 Tas2r14 Receptors, g-protein-coupled Rats Pyy Peptide yy Glucagon-like peptide 1 Glp1 Ghrelin Gastrointestinal tract Gastrointestinal hormones Food intake Eating Cholecystokinin Cck Bodily secretions Animals Agonist
    Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2072-6643
    Author's mail: alba.miguens@urv.cat franciscojavier.avila@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat cristina.torres@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0001-9766-8178 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0002-2917-6910 0000-0001-9691-1906
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/12/12/3784
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 12 (12): 1-13
    APA: Grau-Bove, Carme; Miguens-Gomez, Alba; Gonzalez-Quilen, Carlos; Fernandez-Lopez, Jose-Antonio; Remesar, Xavier; Torres-Fuentes, Cristina; Avila-Roman, (2020). Modulation of food intake by differential TAS2R stimulation in rat. Nutrients, 12(12), 1-13. DOI: 10.3390/nu12123784
    Article's DOI: 10.3390/nu12123784
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Taste receptors, type 2
    Taste
    Tas2r5
    Tas2r39
    Tas2r14
    Receptors, g-protein-coupled
    Rats
    Pyy
    Peptide yy
    Glucagon-like peptide 1
    Glp1
    Ghrelin
    Gastrointestinal tract
    Gastrointestinal hormones
    Food intake
    Eating
    Cholecystokinin
    Cck
    Bodily secretions
    Animals
    Agonist
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar