Author, as appears in the article.: Grau-Bové C; Miguéns-Gómez A; González-Quilen C; Fernández-López JA; Remesar X; Torres-Fuentes C; Ávila-Román J; Rodríguez-Gallego E; Beltrán-Debón R; Blay MT; Terra X; Ardévol A; Pinent M

Department: Bioquímica i Biotecnologia

URV's Author/s: Ardèvol Grau, Anna / Ávila Román, Francisco Javier / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Grau Bové, Maria Carmen / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena / Torres Fuentes, Cristina

Keywords: Tas2r5 Tas2r39 Tas2r14 Pyy Glp1 Food intake Cck Agonist

Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2072-6643

Author's mail: ximena.terra@urv.cat cristina.torres@urv.cat franciscojavier.avila@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat esther.rodriguez@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat mariacarme.grau@estudiants.urv.cat mariacarme.grau@estudiants.urv.cat alba.miguens@estudiants.urv.cat alba.miguens@estudiants.urv.cat

Author identifier: 0000-0003-1043-5844 0000-0002-2917-6910 0000-0001-9766-8178 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Record's date: 2023-06-17

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/12/12/3784

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 12 (12): 1-13

APA: Grau-Bové C; Miguéns-Gómez A; González-Quilen C; Fernández-López JA; Remesar X; Torres-Fuentes C; Ávila-Román J; Rodríguez-Gallego E; Beltrán-Debón R; (2020). Modulation of food intake by differential TAS2R stimulation in rat. Nutrients, 12(12), 1-13. DOI: 10.3390/nu12123784

Article's DOI: 10.3390/nu12123784

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications