Author, as appears in the article.: Mauri M; Calmarza P; Ibarretxe D

Department: Medicina i Cirurgia

URV's Author/s: Ibarretxe Gerediaga, Daiana

Keywords: Severe hypertriglyceridemia Pregnancy Plasma-lipids Maternal hypercholesterolemia Low-density-lipoprotein Lipid profile Lipase gene Hypertriglyceridaemia Hypercholesterolaemia Homozygous familial hypercholesterolemia Familial hypercholesterolaemia Endothelial function Cardiovascular-disease Acute-pancreatitis Acute pancreatitis

Abstract: © 2020 The Authors During pregnancy there is a physiological increase in total cholesterol (TC) and triglycerides (TG) plasma concentrations, due to increased insulin resistance, oestrogens, progesterone, and placental lactogen, although their reference values are not exactly known, TG levels can increase up to 300 mg/dL, and TC can go as high as 350 mg/dL. When the cholesterol concentration exceeds the 95th percentile (familial hypercholesterolaemia (FH) and transient maternal hypercholesterolaemia), there is a predisposition to oxidative stress in foetal vessels, exposing the newborn to a greater fatty streaks formation and a higher risk of atherosclerosis. However, the current treatment of pregnant women with hyperlipidaemia consists of a diet and suspension of lipid-lowering drugs. The most prevalent maternal hypertriglyceridaemia (HTG) is due to secondary causes, like diabetes, obesity, drugs, etc. The case of severe HTG due to genetic causes is less prevalent, and can be a higher risk of maternal-foetal complications, such as, acute pancreatitis (AP), pre-eclampsia, preterm labour, and gestational diabetes. Severe HTG-AP is a rare but potentially lethal pregnancy complication, for the mother and the foetus, usually occurs during the third trimester or in the immediate postpartum period, and there are no specific protocols for its diagnosis and treatment. In conclusion, it is crucial that dyslipidaemia during pregnancy must be carefully evaluated, not just because of the acute complications, but also because of the future cardiovascular morbidity and mortality of the newborn child. That is why the establishment of consensus protocols or guidelines is essential for its management.

Thematic Areas: Pharmacology (medical) Peripheral vascular disease Medicina iii Medicina i Cardiology and cardiovascular medicine

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: daiana.ibarretxe@urv.cat

Record's date: 2023-03-06

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S0214916820301066?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinica E Investigacion En Arteriosclerosis. 33 (1): 41-52

APA: Mauri M; Calmarza P; Ibarretxe D (2021). Dyslipemias and pregnancy, an update. Clinica E Investigacion En Arteriosclerosis, 33(1), 41-52. DOI: 10.1016/j.arteri.2020.10.002

Article's DOI: 10.1016/j.arteri.2020.10.002

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications