Author, as appears in the article.: Castro-Barquero, Sara; Ribo-Coll, Margarita; Lassale, Camille; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Angel Martinez-Gonzalez, Miguel; Sorli, Jose, V; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Alonso-Gomez, Angel M; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Javier Basterra-Gortari, Francisco; Portoles, Olga; Babio, Nancy; Cofan, Montserrat; Ros, Emilio; Estruch, Ramon; Hernaez, Alvaro
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Keywords: Vitamin k epoxide reductases; Time factors; Randomized controlled trials; Prevention; Platelet aggregation inhibitors; Olive oil; Nuts; Middle aged; Mediterranean diet; Male; Humans; Heart disease risk factors; Fibrinolytic agents; Female; Enzyme inhibitors; Diet, mediterranean; Diet, fat-restricted; Cardiovascular diseases; Aged; 4-hydroxycoumarins
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat; nancy.babio@urv.cat
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/12/12/3895
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 12 (12): 1-14
APA: Castro-Barquero, Sara; Ribo-Coll, Margarita; Lassale, Camille; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Angel Martinez-Gonzalez, Miguel; (2020). Mediterranean diet decreases the initiation of use of vitamin k epoxide reductase inhibitors and their associated cardiovascular risk: A randomized controlled trial. Nutrients, 12(12), 1-14. DOI: 10.3390/nu12123895
Article's DOI: 10.3390/nu12123895
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV