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Sex and exposure to postnatal chlorpyrifos influence the epigenetics of feeding-related genes in a transgenic apoe mouse model: Long-term implications on body weight after a high-fat diet

  • Identification data

    Identifier: imarina:9139028
    Authors:
    Guardia-Escote LBlanco JBasaure PBiosca-Brull JVerkaik-Schakel RNCabré MPeris-Sampedro FPérez-Fernández CSánchez-Santed FPlösch TDomingo JLColomina MT
    Abstract:
    © 2020 by the authors. Li-censee MDPI, Basel, Switzerland. Developmental exposure to toxicants and diet can interact with an individual’s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal CPF exposure, APOE genotype, and sex, and how these modifications impact on the metabolic response to a high-fat diet (HFD). Both male and female apoE3-and apoE4-TR mice were exposed to CPF on postnatal days 10–15. The DNA methylation pattern of proopiomelanocortin, neuropeptide Y, leptin receptor, and insulin-like growth factor 2 was studied in the hypothalamus. At adulthood, the mice were given a HFD for eight weeks. The results highlight the importance of sex in the epigenetic regulation and the implication of CPF treatment and APOE genotype. The body weight progression exhibited sex-dimorphic differences, apoE4-TR males being the most susceptible to the effects induced by CPF and HFD. Overall, these results underscore the pivotal role of sex, APOE genotype, and developmental exposure to CPF on subsequent metabolic disturbances later in life and show that sex is a key variable in epigenetic regulation.
  • Others:

    Author, as appears in the article.: Guardia-Escote L; Blanco J; Basaure P; Biosca-Brull J; Verkaik-Schakel RN; Cabré M; Peris-Sampedro F; Pérez-Fernández C; Sánchez-Santed F; Plösch T; Domingo JL; Colomina MT
    Department: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia
    URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
    Keywords: High-fat diet Feeding control Epigenetics Chlorpyrifos Apoe
    Abstract: © 2020 by the authors. Li-censee MDPI, Basel, Switzerland. Developmental exposure to toxicants and diet can interact with an individual’s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal CPF exposure, APOE genotype, and sex, and how these modifications impact on the metabolic response to a high-fat diet (HFD). Both male and female apoE3-and apoE4-TR mice were exposed to CPF on postnatal days 10–15. The DNA methylation pattern of proopiomelanocortin, neuropeptide Y, leptin receptor, and insulin-like growth factor 2 was studied in the hypothalamus. At adulthood, the mice were given a HFD for eight weeks. The results highlight the importance of sex in the epigenetic regulation and the implication of CPF treatment and APOE genotype. The body weight progression exhibited sex-dimorphic differences, apoE4-TR males being the most susceptible to the effects induced by CPF and HFD. Overall, these results underscore the pivotal role of sex, APOE genotype, and developmental exposure to CPF on subsequent metabolic disturbances later in life and show that sex is a key variable in epigenetic regulation.
    Thematic Areas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.blanco@urv.cat maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat mariateresa.colomina@urv.cat
    Author identifier: 0000-0001-8016-0984 0000-0003-4124-8603 0000-0001-6647-9470 0000-0002-5619-4874
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1660-4601/18/1/184
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Environmental Research And Public Health. 18 (1): 1-17
    APA: Guardia-Escote L; Blanco J; Basaure P; Biosca-Brull J; Verkaik-Schakel RN; Cabré M; Peris-Sampedro F; Pérez-Fernández C; Sánchez-Santed F; Plösch T; D (2021). Sex and exposure to postnatal chlorpyrifos influence the epigenetics of feeding-related genes in a transgenic apoe mouse model: Long-term implications on body weight after a high-fat diet. International Journal Of Environmental Research And Public Health, 18(1), 1-17. DOI: 10.3390/ijerph18010184
    Article's DOI: 10.3390/ijerph18010184
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Pollution,Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health
    High-fat diet
    Feeding control
    Epigenetics
    Chlorpyrifos
    Apoe
    Zootecnia / recursos pesqueiros
    Serviço social
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Pollution
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Health, toxicology and mutagenesis
    Geografía
    Geociências
    Farmacia
    Environmental studies
    Environmental sciences
    Ensino
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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