Author, as appears in the article.: Schellekens, Harriet; Torres-Fuentes, Cristina; van de Wouw, Marcel; Long-Smith, Caitriona M; Mitchell, Avery; Strain, Conall; Berding, Kirsten; Bastiaanssen, Thomaz F S; Rea, Kieran; Golubeva, Anna V; Arboleya, Silvia; Verpaalen, Mathieu; Pusceddu, Matteo M; Murphy, Amy; Fouhy, Fiona; Murphy, Kiera; Ross, Paul; Roy, Bernard L; Stanton, Catherine; Dinan, Timothy G; Cryan, John F
Department: Bioquímica i Biotecnologia
URV's Author/s: Torres Fuentes, Cristina
Keywords: Translational research, biomedical Translational Rodentia Probiotics Probiotic Obesity Neuropeptides Mice Male Leptin Host microbial interactions Gut microbiota Glucose Ghrelin Fasting blood glucose Energy metabolism Disease resistance Disease models, animal Dietary supplements Diet, high-fat Cortisol Body weight Biomarkers Bifidobacterium longum Animals Adrenal cortex hormones Adiposity
Abstract: © 2020 The Authors Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. Funding: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.
Thematic Areas: Saúde coletiva Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i General medicine General biochemistry,genetics and molecular biology Ciências biológicas ii Biotecnología Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: cristina.torres@urv.cat
Author identifier: 0000-0002-2917-6910
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Ebiomedicine. 63 103176-
APA: Schellekens, Harriet; Torres-Fuentes, Cristina; van de Wouw, Marcel; Long-Smith, Caitriona M; Mitchell, Avery; Strain, Conall; Berding, Kirsten; Basti (2021). Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human. Ebiomedicine, 63(), 103176-. DOI: 10.1016/j.ebiom.2020.103176
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV