Articles producció científica> Bioquímica i Biotecnologia

Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human

  • Identification data

    Identifier: imarina:9139070
    Authors:
    Schellekens HTorres-Fuentes Cvan de Wouw MLong-Smith CMMitchell AStrain CBerding KBastiaanssen TFSRea KGolubeva AVArboleya SVerpaalen MPusceddu MMMurphy AFouhy FMurphy KRoss PRoy BLStanton CDinan TGCryan JF
    Abstract:
    © 2020 The Authors Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. Funding: This r
  • Others:

    Author, as appears in the article.: Schellekens H; Torres-Fuentes C; van de Wouw M; Long-Smith CM; Mitchell A; Strain C; Berding K; Bastiaanssen TFS; Rea K; Golubeva AV; Arboleya S; Verpaalen M; Pusceddu MM; Murphy A; Fouhy F; Murphy K; Ross P; Roy BL; Stanton C; Dinan TG; Cryan JF
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Torres Fuentes, Cristina
    Keywords: Translational Probiotic Obesity Gut microbiota Ghrelin Fasting blood glucose Cortisol Bifidobacterium longum
    Abstract: © 2020 The Authors Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. Funding: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.
    Thematic Areas: Saúde coletiva Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i General medicine General biochemistry,genetics and molecular biology Ciências biológicas ii Biotecnología Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: cristina.torres@urv.cat
    Author identifier: 0000-0002-2917-6910
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S2352396420305521
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Ebiomedicine. 63 103176-
    APA: Schellekens H; Torres-Fuentes C; van de Wouw M; Long-Smith CM; Mitchell A; Strain C; Berding K; Bastiaanssen TFS; Rea K; Golubeva AV; Arboleya S; Verp (2021). Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human. Ebiomedicine, 63(), 103176-. DOI: 10.1016/j.ebiom.2020.103176
    Article's DOI: 10.1016/j.ebiom.2020.103176
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental
    Translational
    Probiotic
    Obesity
    Gut microbiota
    Ghrelin
    Fasting blood glucose
    Cortisol
    Bifidobacterium longum
    Saúde coletiva
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    General biochemistry,genetics and molecular biology
    Ciências biológicas ii
    Biotecnología
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
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