Author, as appears in the article.: Schellekens H; Torres-Fuentes C; van de Wouw M; Long-Smith CM; Mitchell A; Strain C; Berding K; Bastiaanssen TFS; Rea K; Golubeva AV; Arboleya S; Verpaalen M; Pusceddu MM; Murphy A; Fouhy F; Murphy K; Ross P; Roy BL; Stanton C; Dinan TG; Cryan JF
Department: Bioquímica i Biotecnologia
URV's Author/s: Torres Fuentes, Cristina
Keywords: Bifidobacterium longum Cortisol Fasting blood glucose Ghrelin Gut microbiota Obesity Probiotic Translational
Abstract: © 2020 The Authors Background: The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B. longum APC1472 supplementation reduces body-mass index (BMI) in healthy overweight/obese individuals as the primary outcome. B. longum APC1472 effects on waist-to-hip ratio (W/H ratio) and on obesity-associated plasma biomarkers were analysed as secondary outcomes. Methods: B. longum APC1472 was administered to HFD-fed C57BL/6 mice in drinking water for 16 weeks. In the human intervention trial, participants received B. longum APC1472 or placebo supplementation for 12 weeks, during which primary and secondary outcomes were measured at the beginning and end of the intervention. Findings: B. longum APC1472 supplementation was associated with decreased bodyweight, fat depots accumulation and increased glucose tolerance in HFD-fed mice. While, in healthy overweight/obese adults, the supplementation of B. longum APC1472 strain did not change primary outcomes of BMI (0.03, 95% CI [-0.4, 0.3]) or W/H ratio (0.003, 95% CI [-0.01, 0.01]), a positive effect on the secondary outcome of fasting blood glucose levels was found (-0.299, 95% CI [-0.44, -0.09]). Interpretation: This study shows a positive translational effect of B. longum APC1472 on fasting blood glucose from a preclinical mouse model of obesity to a human intervention study in otherwise healthy overweight and obese individuals. This highlights the promising potential of B. longum APC1472 to be developed as a valuable supplement in reducing specific markers of obesity. Funding: This research was funded in part by Science Foundation Ireland in the form of a Research Centre grant (SFI/12/RC/2273) to APC Microbiome Ireland and by a research grant from Cremo S.A.
Thematic Areas: Biochemistry, genetics and molecular biology (all) Biochemistry, genetics and molecular biology (miscellaneous) Biotecnología Ciências biológicas ii General biochemistry,genetics and molecular biology General medicine Medicina i Medicina ii Medicina iii Medicine (miscellaneous) Medicine, research & experimental Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: cristina.torres@urv.cat
Author identifier: 0000-0002-2917-6910
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S2352396420305521
Papper original source: Ebiomedicine. 63 103176-
APA: Schellekens H; Torres-Fuentes C; van de Wouw M; Long-Smith CM; Mitchell A; Strain C; Berding K; Bastiaanssen TFS; Rea K; Golubeva AV; Arboleya S; Verp (2021). Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human. Ebiomedicine, 63(), 103176-. DOI: 10.1016/j.ebiom.2020.103176
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.ebiom.2020.103176
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV