Articles producció científica> Bioquímica i Biotecnologia

Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice

  • Identification data

    Identifier: imarina:9149609
    Authors:
    Cano AEttcheto MEspina MAuladell CFolch JKühne BABarenys MSánchez-López ESouto EBGarcía MLTurowski PCamins A
    Abstract:
    © 2021 Future Medicine Ltd. Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntington's disease (HD)-like symptoms in mice. Materials & methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-administered and behavioral motor assessments and striatal histology performed after 5 days. Results: EGCG/AA NPs were significantly more effective than free EGCG in reducing motor disturbances and depression-like behavior associated with 3-nitropropionic acid toxicity. EGCG/AA NPs treatment also mitigated neuroinflammation and prevented neuronal loss. Conclusion: NP encapsulation enhances therapeutic robustness of EGCG in this model of HD symptomatology. Together with our previous findings, this highlights the potential of EGCG/AA NPs in the symptomatic treatment of neurodegenerative diseases.
  • Others:

    Author, as appears in the article.: Cano A; Ettcheto M; Espina M; Auladell C; Folch J; Kühne BA; Barenys M; Sánchez-López E; Souto EB; García ML; Turowski P; Camins A
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Folch Lopez, Jaume
    Keywords: Polymeric nanoparticles Plga-peg Neurodegenerative diseases Huntington's disease Epigallocatechin-3-gallate 3-nitropropionic acid
    Abstract: © 2021 Future Medicine Ltd. Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntington's disease (HD)-like symptoms in mice. Materials & methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-administered and behavioral motor assessments and striatal histology performed after 5 days. Results: EGCG/AA NPs were significantly more effective than free EGCG in reducing motor disturbances and depression-like behavior associated with 3-nitropropionic acid toxicity. EGCG/AA NPs treatment also mitigated neuroinflammation and prevented neuronal loss. Conclusion: NP encapsulation enhances therapeutic robustness of EGCG in this model of HD symptomatology. Together with our previous findings, this highlights the potential of EGCG/AA NPs in the symptomatic treatment of neurodegenerative diseases.
    Thematic Areas: Química Nanoscience and nanotechnology Nanoscience & nanotechnology Medicine (miscellaneous) Medicina ii Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General medicine General materials science Farmacia Engenharias ii Economia Development Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología Biotechnology & applied microbiology Biomedical engineering Bioengineering Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jaume.folch@urv.cat
    Author identifier: 0000-0002-5051-8858
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2020-0239
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nanomedicine. 16 (1): 19-35
    APA: Cano A; Ettcheto M; Espina M; Auladell C; Folch J; Kühne BA; Barenys M; Sánchez-López E; Souto EB; García ML; Turowski P; Camins A (2021). Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice. Nanomedicine, 16(1), 19-35. DOI: 10.2217/nnm-2020-0239
    Article's DOI: 10.2217/nnm-2020-0239
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Bioengineering,Biomedical Engineering,Biotechnology & Applied Microbiology,Development,Materials Science (Miscellaneous),Medicine (Miscellaneous),Nanoscience & Nanotechnology,Nanoscience and Nanotechnology
    Polymeric nanoparticles
    Plga-peg
    Neurodegenerative diseases
    Huntington's disease
    Epigallocatechin-3-gallate
    3-nitropropionic acid
    Química
    Nanoscience and nanotechnology
    Nanoscience & nanotechnology
    Medicine (miscellaneous)
    Medicina ii
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    Interdisciplinar
    General medicine
    General materials science
    Farmacia
    Engenharias ii
    Economia
    Development
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência da computação
    Biotecnología
    Biotechnology & applied microbiology
    Biomedical engineering
    Bioengineering
    Biodiversidade
    Astronomia / física
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