Author, as appears in the article.: Cano A; Ettcheto M; Espina M; Auladell C; Folch J; Kühne BA; Barenys M; Sánchez-López E; Souto EB; García ML; Turowski P; Camins A
Department: Bioquímica i Biotecnologia
URV's Author/s: Folch Lopez, Jaume
Keywords: Polymeric nanoparticles Plga-peg Neurodegenerative diseases Huntington's disease Epigallocatechin-3-gallate 3-nitropropionic acid
Abstract: © 2021 Future Medicine Ltd. Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntington's disease (HD)-like symptoms in mice. Materials & methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-administered and behavioral motor assessments and striatal histology performed after 5 days. Results: EGCG/AA NPs were significantly more effective than free EGCG in reducing motor disturbances and depression-like behavior associated with 3-nitropropionic acid toxicity. EGCG/AA NPs treatment also mitigated neuroinflammation and prevented neuronal loss. Conclusion: NP encapsulation enhances therapeutic robustness of EGCG in this model of HD symptomatology. Together with our previous findings, this highlights the potential of EGCG/AA NPs in the symptomatic treatment of neurodegenerative diseases.
Thematic Areas: Química Nanoscience and nanotechnology Nanoscience & nanotechnology Medicine (miscellaneous) Medicina ii Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General medicine General materials science Farmacia Engenharias ii Economia Development Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología Biotechnology & applied microbiology Biomedical engineering Bioengineering Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jaume.folch@urv.cat
Author identifier: 0000-0002-5051-8858
Record's date: 2024-06-22
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2020-0239
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nanomedicine. 16 (1): 19-35
APA: Cano A; Ettcheto M; Espina M; Auladell C; Folch J; Kühne BA; Barenys M; Sánchez-López E; Souto EB; García ML; Turowski P; Camins A (2021). Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice. Nanomedicine, 16(1), 19-35. DOI: 10.2217/nnm-2020-0239
Article's DOI: 10.2217/nnm-2020-0239
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV