Author, as appears in the article.: Lopez-Fernandez-Sobrino, Raul; Soliz-Rueda, Jorge R; Margalef, Maria; Arola-Arnal, Anna; Suarez, Manuel; Bravo, Francisca, I; Muguerza, Begona
Department: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
URV's Author/s: Alkhoury, Nadine / Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel
Keywords: Winery by-product Wine Vitis Shr Rats, inbred wky Rats, inbred shr Rats Polyphenols Male Hypertension Captopril Cabernet grape variety Blood pressure Antihypertensive agents Animals Angiotensin-converting enzyme inhibitors
Abstract: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Wine lees (WL) are by-products generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar– Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to commercial use within the wine industry.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat jorgericardo.soliz@urv.cat manuel.suarez@urv.cat franciscaisabel.bravo@urv.cat anna.arola@urv.cat begona.muguerza@urv.cat
Author identifier: 0000-0003-0122-8253 0000-0002-6468-3088 0000-0001-6529-1345 0000-0001-7384-8588
Record's date: 2025-01-28
Journal volume: 13
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 13 (2): 1-17
APA: Lopez-Fernandez-Sobrino, Raul; Soliz-Rueda, Jorge R; Margalef, Maria; Arola-Arnal, Anna; Suarez, Manuel; Bravo, Francisca, I; Muguerza, Begona (2021). Ace inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile. Nutrients, 13(2), 1-17. DOI: 10.3390/nu13020679
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV