Author, as appears in the article.: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, J Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Díaz López, Andres / Ruiz Garcia, Verónica / Salas Salvadó, Jorge
Keywords: Weight loss; Waist circumference; Systolic blood pressure; Sensitivity analysis; Randomized controlled trial; Randomization; Questionnaire; Primary medical care; Predimed-plus; Physical activity; Pathophysiology; Outcome assessment; Obesity; Multicenter study; Monte carlo method; Monounsaturated fatty acid; Middle aged; Mediterranean diet; Male; Major clinical study; Low density lipoprotein cholesterol; Lifestyle; Life style; Kidney function tests; Kidney function test; Kidney function; Kidney; Incidence; Humans; Human experiment; Human; High density lipoprotein cholesterol; Glycemic index; Glucose metabolism; Glucose blood level; Glomerulus filtration rate; Glomerular filtration rate; Female; Estimated glomerular filtration rate; Energy expenditure; Dyslipidemia; Disease exacerbation; Dipeptidyl carboxypeptidase; Dietary intervention; Diastolic blood pressure; Diabetes mellitus; Controlled study; Comparative effectiveness; Clinical trial; Cardiovascular risk; Cardiovascular disease; Body weight loss; Body mass; Bariatric surgery; Article; Albumin to creatinine ratio; Aged
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m(2)) and micro- to macroalbuminuria (UACR >= 30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m(2)) to mildly impaired GFR (60 to <90 mL/min/1.73 m(2)) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m(2) in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m(2); 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
Thematic Areas: Urology & nephrology; Saúde coletiva; Odontología; Nutrição; Nephrology; Medicina ii; Medicina i; General medicine; Farmacia; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.ruiz@urv.cat; andres.diaz@urv.cat; nerea.becerra@urv.cat; veronica.ruiz@urv.cat; monica.bullo@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat
Record's date: 2025-02-08
Paper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.karger.com/Article/FullText/513664
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: American Journal Of Nephrology. 52 (1): 1-14
APA: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Je (2021). Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. American Journal Of Nephrology, 52(1), 1-14. DOI: 10.1159/000513664
Article's DOI: 10.1159/000513664
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV