Articles producció científica> Bioquímica i Biotecnologia

Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

  • Identification data

    Identifier: imarina:9162435
  • Authors:

    Diaz-Lopez, Andres
    Becerra-Tomas, Nerea
    Ruiz, Veronica
    Toledo, Estefania
    Babio, Nancy
    Corella, Dolores
    Fito, Montse
    Romaguera, Dora
    Vioque, Jesus
    Alonso-Gomez, Angel M.
    Warnberg, Julia
    Martinez, J. Alfredo
    Serra-Majem, Luis
    Estruch, Ramon
    Tinahones, Francisco J.
    Lapetra, Jose
    Pinto, Xavier
    Tur, Josep A.
    Lopez-Miranda, Jose
    Cano Ibanez, Naomi
    Delgado-Rodriguez, Miguel
    Matia-Martin, Pilar
    Daimiel, Lidia
    Antonio de Paz, Jose
    Vidal, Josep
    Vazquez, Clotilde
    Ruiz-Canela, Miguel
    Bullo, Monica
    Sorli, Jose, V
    Goday, Albert
    Fiol, Miquel
    Garcia-de-la-Hera, Manoli
    Sierra, Lucas Tojal
    Perez-Farinos, Napoleon
    Zulet, Maria Angeles
    Sanchez-Villegas, Almudena
    Sacanella, Emilio
    Carlos Fernandez-Garcia, Jose
    Manuel Santos-Lozano, Jose
    Gimenez-Gracia, Miquel
    Bibiloni, Maria Del Mar
    Diez-Espino, Javier
    Ortega-Azorin, Carolina
    Castaner, Olga
    Morey, Marga
    Torres-Collado, Laura
    Sorto Sanchez, Carolina
    Angel Munoz, Miguel
    Ros, Emilio
    Martinez-Gonzalez, Miguel A.
    Salas-Salvado, Jordi
    PREDIMED-Plus Investigators
  • Others:

    Author, as appears in the article.: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi;PREDIMED-Plus Investigators
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Díaz López, Andres / Ruiz Garcia, Verónica / Salas Salvadó, Jorge
    Keywords: Weight loss Waist circumference Systolic blood pressure Sensitivity analysis Randomized controlled trial Randomization Questionnaire Primary medical care Predimed-plus Physical activity Pathophysiology Outcome assessment Obesity Multicenter study Monte carlo method Monounsaturated fatty acid Middle aged Mediterranean diet Male Major clinical study Low density lipoprotein cholesterol Lifestyle Life style Kidney function tests Kidney function test Kidney function Kidney Incidence Humans Human experiment Human High density lipoprotein cholesterol Glycemic index Glucose metabolism Glucose blood level Glomerulus filtration rate Glomerular filtration rate Female Estimated glomerular filtration rate Energy expenditure Dyslipidemia Disease exacerbation Dipeptidyl carboxypeptidase Dietary intervention Diastolic blood pressure Diabetes mellitus Controlled study Comparative effectiveness Clinical trial Cardiovascular risk Cardiovascular disease Body weight loss Body mass Bariatric surgery Article Albumin to creatinine ratio Aged
    Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m(2)) and micro- to macroalbuminuria (UACR >= 30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m(2)) to mildly impaired GFR (60 to <90 mL/min/1.73 m(2)) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m(2) in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m(2); 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
    Thematic Areas: Urology & nephrology Saúde coletiva Odontología Nutrição Nephrology Medicina ii Medicina i General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: veronica.ruiz@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat veronica.ruiz@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-7500-5629 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.karger.com/Article/FullText/513664
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Nephrology. 52 (1): 1-14
    APA: Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Je (2021). Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. American Journal Of Nephrology, 52(1), 1-14. DOI: 10.1159/000513664
    Article's DOI: 10.1159/000513664
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Nephrology,Urology & Nephrology
    Weight loss
    Waist circumference
    Systolic blood pressure
    Sensitivity analysis
    Randomized controlled trial
    Randomization
    Questionnaire
    Primary medical care
    Predimed-plus
    Physical activity
    Pathophysiology
    Outcome assessment
    Obesity
    Multicenter study
    Monte carlo method
    Monounsaturated fatty acid
    Middle aged
    Mediterranean diet
    Male
    Major clinical study
    Low density lipoprotein cholesterol
    Lifestyle
    Life style
    Kidney function tests
    Kidney function test
    Kidney function
    Kidney
    Incidence
    Humans
    Human experiment
    Human
    High density lipoprotein cholesterol
    Glycemic index
    Glucose metabolism
    Glucose blood level
    Glomerulus filtration rate
    Glomerular filtration rate
    Female
    Estimated glomerular filtration rate
    Energy expenditure
    Dyslipidemia
    Disease exacerbation
    Dipeptidyl carboxypeptidase
    Dietary intervention
    Diastolic blood pressure
    Diabetes mellitus
    Controlled study
    Comparative effectiveness
    Clinical trial
    Cardiovascular risk
    Cardiovascular disease
    Body weight loss
    Body mass
    Bariatric surgery
    Article
    Albumin to creatinine ratio
    Aged
    Urology & nephrology
    Saúde coletiva
    Odontología
    Nutrição
    Nephrology
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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