Author, as appears in the article.: Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Papandreou, Christopher; Hansen, Thea T.; Harrold, Jo A.; Finlayson, Graham; Blundell, John E.; Sjodin, Anders; Halford, Jason C. G.; Bullo, Monica;

Department: Bioquímica i Biotecnologia

URV's Author/s: Bulló Bonet, Mònica / CAMACHO BARCIA, MARIA LUCIA / García Gavilán, Jesús Francisco

Keywords: Young adult Visual analog scale Sucrose Statistical model Sphingomyelins Sphingomyelin Satiety Satiation Randomized controlled trials as topic Randomized controlled trial (topic) Postprandial state Postprandial period Physiology Phosphatidylcholines Phosphatidylcholine Overweight Obesity Multicenter study Middle aged Metabolomics Metabolome Male Linoleic acid Linear models Humans Human Glycine Food intake Female Fasting Double-blind method Double blind procedure Diet restriction Cross-sectional study Cross-sectional studies Clinical trial Blood Area under the curve Area under curve Appetite regulation Aged Adult

Abstract: Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the Satiety Innovation-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson's correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jesusfrancisco.garcia@urv.cat monica.bullo@urv.cat jesusfrancisco.garcia@urv.cat

Author identifier: 0000-0002-0218-7046

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/13/2/549

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 13 (2): 1-11

APA: Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Papandreou, Christopher; Hansen, Thea T.; Harrold, Jo A.; Finlayson, Graham; Blundell, John E.; Sjodin, (2021). Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study. Nutrients, 13(2), 1-11. DOI: 10.3390/nu13020549

Article's DOI: 10.3390/nu13020549

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications