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Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study

  • Identification data

    Identifier: imarina:9172956
    Authors:
    Camacho-Barcia, LuciaGarcia-Gavilan, JesusPapandreou, ChristopherHansen, Thea THarrold, Jo AFinlayson, GrahamBlundell, John ESjodin, AndersHalford, Jason C GBullo, Monica
    Abstract:
    Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the Satiety Innovation-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson's correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.
  • Others:

    Author, as appears in the article.: Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Papandreou, Christopher; Hansen, Thea T; Harrold, Jo A; Finlayson, Graham; Blundell, John E; Sjodin, Anders; Halford, Jason C G; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / CAMACHO BARCIA, MARIA LUCIA / García Gavilán, Jesús Francisco
    Keywords: Young adult Visual analog scale Sucrose Statistical model Sphingomyelins Sphingomyelin Satiety Satiation Randomized controlled trials as topic Randomized controlled trial (topic) Postprandial state Postprandial period Physiology Phosphatidylcholines Phosphatidylcholine Overweight Obesity Multicenter study Middle aged Metabolomics Metabolome Male Linoleic acid Linear models Humans Human Glycine Food intake Female Fasting Double-blind method Double blind procedure Diet restriction Cross-sectional study Cross-sectional studies Clinical trial Blood Area under the curve Area under curve Appetite regulation Aged Adult
    Abstract: Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the Satiety Innovation-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson's correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat monica.bullo@urv.cat
    Author identifier: 0000-0002-0218-7046
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/2/549
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (2): 1-11
    APA: Camacho-Barcia, Lucia; Garcia-Gavilan, Jesus; Papandreou, Christopher; Hansen, Thea T; Harrold, Jo A; Finlayson, Graham; Blundell, John E; Sjodin, And (2021). Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study. Nutrients, 13(2), 1-11. DOI: 10.3390/nu13020549
    Article's DOI: 10.3390/nu13020549
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Young adult
    Visual analog scale
    Sucrose
    Statistical model
    Sphingomyelins
    Sphingomyelin
    Satiety
    Satiation
    Randomized controlled trials as topic
    Randomized controlled trial (topic)
    Postprandial state
    Postprandial period
    Physiology
    Phosphatidylcholines
    Phosphatidylcholine
    Overweight
    Obesity
    Multicenter study
    Middle aged
    Metabolomics
    Metabolome
    Male
    Linoleic acid
    Linear models
    Humans
    Human
    Glycine
    Food intake
    Female
    Fasting
    Double-blind method
    Double blind procedure
    Diet restriction
    Cross-sectional study
    Cross-sectional studies
    Clinical trial
    Blood
    Area under the curve
    Area under curve
    Appetite regulation
    Aged
    Adult
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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