Author, as appears in the article.: Miralles-Perez, Bernat; Nogues, Maria Rosa; Sanchez-Martos, Vanessa; Taltavull, Nuria; Mendez, Lucia; Medina, Isabel; Ramos-Romero, Sara; Torres, Josep L.; Romeu, Marta;

Department: Ciències Mèdiques Bàsiques

e-ISSN: 2304-8158

URV's Author/s: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Sánchez Martos, Vanessa / Taltavull Anglada, Núria

Keywords: Transaminases Oxidative stress Inflammation Fish oil Dyslipidemia D-fagomine

Abstract: The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (omega-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet. This study aimed to examine the effects of combined supplementation with FG and omega-3 PUFA on dyslipidemia, transaminases, interleukin-6, and oxidative stress. Forty-five male Sprague-Dawley rats were fed a standard diet, an HF diet, an HF diet supplemented with FG, an HF diet supplemented with omega-3 PUFA, or an HF diet supplemented with FG and omega-3 PUFA for 21 weeks. Triacylglycerol, cholesterol, aspartate aminotransferase, alanine aminotransferase, and interleukin-6 were measured. The assessment of oxidative stress included plasma antioxidant capacity, antioxidant enzyme activities, glutathione content, lipid peroxidation, and protein carbonylation. The combined supplementation with FG and omega-3 PUFA did not attenuate the slight accumulation of liver cholesterol induced by the HF diet but normalized the plasma alanine aminotransferase activity. Rats fed the HF diet supplemented with the combination showed a lower amount of plasma interleukin-6 than those fed a standard diet. The combination attenuated oxidative damage induced by the HF diet, decreased antioxidant enzyme activities, and enhanced glutathione status. The beneficial effects of the combination of FG and omega-3 PUFA on oxidative stress and related risk factors in pre-obese rats were mainly modulated by omega-3 PUFA.

Thematic Areas: Plant science Microbiology Health professions (miscellaneous) Health (social science) Food science & technology Food science

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: bernat.miralles@urv.cat nuria.taltavull@urv.cat vanessa.sanchez@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat vanessa.sanchez@urv.cat bernat.miralles@urv.cat

Author identifier: 0000-0003-1294-7069 0000-0002-3340-2650 0000-0003-4626-5672 0000-0002-2131-1858 0000-0003-1294-7069

Record's date: 2023-02-23

Journal volume: 10

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2304-8158/10/2/332

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Foods. 10 (2):

APA: Miralles-Perez, Bernat; Nogues, Maria Rosa; Sanchez-Martos, Vanessa; Taltavull, Nuria; Mendez, Lucia; Medina, Isabel; Ramos-Romero, Sara; Torres, Jose (2021). The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats. Foods, 10(2), -. DOI: 10.3390/foods10020332

Article's DOI: 10.3390/foods10020332

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications