Articles producció científica> Bioquímica i Biotecnologia

Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome

  • Identification data

    Identifier: imarina:9173237
    Handle: https://hdl.handle.net/20.500.11797/imarina9173237
    Authors:
    Atzeni, AlessandroGalie, SerenaMuralidharan, JananeeBabio, NancyTinahones, Francisco JoseVioque, JesusCorella, DoloresCastaner, OlgaVidal, JosepMoreno-Indias, IsabelTorres-Collado, LauraFernandez-Carrion, RebecaFito, MontserratOlbeyra, RominaMartinez-Gonzalez, Miguel AngelBullo, MonicaSalas-Salvado, Jordi
    Abstract:
    Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.

  • Others:

    Author, as appears in the article.: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Montserrat; Olbeyra, Romina; Martinez-Gonzalez, Miguel Angel; Bullo, Monica; Salas-Salvado, Jordi
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Galiè, Serena / Muralidharan, Jananee / Salas Salvadó, Jorge
    Keywords: Weight loss Obesity Gut microbiota Clinical trial Bmi 16s sequencing
    Abstract: Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
    Thematic Areas: Virology Microbiology (medical) Microbiology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-2607/9/2/346
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Microorganisms. 9 (2): 1-13
    APA: Atzeni, Alessandro; Galie, Serena; Muralidharan, Jananee; Babio, Nancy; Tinahones, Francisco Jose; Vioque, Jesus; Corella, Dolores; Castaner, Olga; Vi (2021). Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome. Microorganisms, 9(2), 1-13. DOI: 10.3390/microorganisms9020346
    Article's DOI: 10.3390/microorganisms9020346
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications

  • Keywords:

    Microbiology,Microbiology (Medical),Virology
    Weight loss
    Obesity
    Gut microbiota
    Clinical trial
    Bmi
    16s sequencing
    Virology
    Microbiology (medical)
    Microbiology

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