Author, as appears in the article.: Sandoval-Ramírez BA; Catalán Ú; Pedret A; Valls RM; Motilva MJ; Rubió L; Solà R

Department: Medicina i Cirurgia

URV's Author/s: Catalán Santos, Úrsula / Pedret Figuerola, Anna / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria

Keywords: Resveratrol Polyphenols Phenolic compounds Microbiota Intestinal Integrity Inflammation Health Gut Epithelial tight junctions Dysfunction Disruption Critical illness Capacity Barrier Apoptosis

Abstract: Background & aims: The integrity of the intestinal barrier in the diseased is key to prevent further complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals. Methods: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools. Results: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n = 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n = 2), curcumin (n = 1), genistein (n = 1), chlorogenic acid (n = 1), grape pomace (n = 1), olive leaf (n = 1) or cranberry extract (n = 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-α, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia. Conclusions: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: ursula.catalan@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat

Author identifier: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942

Record's date: 2023-03-06

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30499-4/fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical Nutrition. 40 (4): 1719-1732

APA: Sandoval-Ramírez BA; Catalán Ú; Pedret A; Valls RM; Motilva MJ; Rubió L; Solà R (2021). Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies. Clinical Nutrition, 40(4), 1719-1732. DOI: 10.1016/j.clnu.2020.09.027

Article's DOI: 10.1016/j.clnu.2020.09.027

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications