Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters

  • Identification data

    Identifier: imarina:9187111
    Authors:
    Kapruwan, PankajAcosta, Laura KFerre-Borrull, JosepMarsal, Lluis F
    Abstract:
    In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
  • Others:

    Author, as appears in the article.: Kapruwan, Pankaj; Acosta, Laura K; Ferre-Borrull, Josep; Marsal, Lluis F
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Acosta Capilla, Laura Karen / Ferré Borrull, José / Kapruwan, Pankaj / Marsal Garví, Luis Francisco
    Keywords: Rhodamine 6g Polyelectrolytes Photonic crystals Optical monitoring Nanoporous anodic alumina
    Abstract: In this work, a methodology that exploits the optical properties of the nanoporous anodic alumina gradient index filters (NAA-GIFs) has been developed and applied to evaluate in real time the release dynamics of a cargo molecule, acting as a model drug, filling the pores. NAA-GIFs with two photonic stopbands (PSBs) were prepared with one of its stop bands in the same absorption wavelength range of the cargo molecule, whereas the second stopband away from this absorption range. Numerical simulation and experiments confirm that the relative height of the high reflectance bands in the reflectance spectra of NAA-GIFs filled with the drug can be related to the relative amount of drug filling the pores. This property has been applied in a flow cell setup to measure in real-time the release dynamics of NAA-GIFs with the inner pore surface modified by layer-by-layer deposition of polyelectrolytes and loaded with the cargo molecule. The methodology developed in this work acts as a tool for the study of drug delivery from porous nanostructures.
    Thematic Areas: Physics, applied Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) General materials science General chemical engineering Engenharias ii Chemistry, multidisciplinary Chemical engineering (miscellaneous) Chemical engineering (all)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: pankaj.kapruwan1@estudiants.urv.cat pankaj.kapruwan1@estudiants.urv.cat laurakaren.acosta@urv.cat josep.ferre@urv.cat lluis.marsal@urv.cat
    Author identifier: 0000-0002-5210-5133 0000-0002-5976-1408
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2079-4991/11/3/730
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nanomaterials. 11 (3): 1-16
    APA: Kapruwan, Pankaj; Acosta, Laura K; Ferre-Borrull, Josep; Marsal, Lluis F (2021). Optical Platform to Analyze a Model Drug-Loading and Releasing Profile Based on Nanoporous Anodic Alumina Gradient Index Filters. Nanomaterials, 11(3), 1-16. DOI: 10.3390/nano11030730
    Article's DOI: 10.3390/nano11030730
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Chemical Engineering (Miscellaneous),Chemistry, Multidisciplinary,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Nanoscience & Nanotechnology,Physics, Applied
    Rhodamine 6g
    Polyelectrolytes
    Photonic crystals
    Optical monitoring
    Nanoporous anodic alumina
    Physics, applied
    Nanoscience & nanotechnology
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    General materials science
    General chemical engineering
    Engenharias ii
    Chemistry, multidisciplinary
    Chemical engineering (miscellaneous)
    Chemical engineering (all)
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