Author, as appears in the article.: Ribo-Coll, Margarita; Castro-Barquero, Sara; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefania; Sorli, Jose V.; Diaz-Lopez, Andres; Lapetra, Jose; Munoz-Bravo, Carlos; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Castaner, Olga; Fernandez-Lazaro, Cesar I.; Portoles, Olga; Babio, Nancy; Estruch, Ramon; Hernaez, Alvaro;
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
URV's Author/s: Babio Sánchez, Nancy Elvira / Díaz López, Andres
Keywords: Vitamin k epoxide reductase inhibitors Statins Physical activity Mediterranean diet Glucose?lowering drugs Glucose-lowering drugs Fibrates Cardiac glycosides Antiplatelet drugs Antihypertensive drugs Antianginal drugs
Abstract: Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvencion con DIeta MEDiterranea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.
Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andres.diaz@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0003-3527-5277
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/10/3/397
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antioxidants. 10 (3): 1-15
APA: Ribo-Coll, Margarita; Castro-Barquero, Sara; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefania; Sorli, Jose V.; Diaz-Lopez, Andres; (2021). Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study. Antioxidants, 10(3), 1-15. DOI: 10.3390/antiox10030397
Article's DOI: 10.3390/antiox10030397
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV