Author, as appears in the article.: Nunez-Gil, Ivan J.; Fernandez-Ortiz, Antonio; Maroud Eid, Charbel; Huang, Jia; Romero, Rodolfo; Manuel Becerra-Munoz, Victor; Uribarri, Aitor; Feltes, Gisela; Trabatoni, Daniela; Fernandez-Rozas, Inmaculada; Viana-Llamas, Maria C.; Pepe, Martino; Cerrato, Enrico; Bertaina, Maurizio; Astrua, Thamar Capel; Alfonso, Emilio; Castro-Mejia, Alex F.; Raposeiras-Roubin, Sergio; D'Ascenzo, Fabrizio; Espejo Paeres, Carolina; Signes-Costa, Jaime; Bardaji, Alfredo; Fernandez-Perez, Cristina; Marin, Francisco; Fabregat-Andres, Oscar; Akin, Ibrahim; Estrada, Vicente; Macaya, Carlos;Hope COVID-19 Investigators
Department: Medicina i Cirurgia
URV's Author/s: Bardají Ruiz, Alfredo
Keywords: Registry Prognosis Myocardial-infarction Mortality Heart disease Covid-19 Cardiovascular-disease Cardiology Ace2 expression
Abstract: Background: The presence of any underlying heart condition could influence outcomes during the coronavirus disease 2019 (COVID-19).
Methods: The registry HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19, NCT04334291) is an international ambispective study, enrolling COVID-19 patients discharged from hospital, dead or alive.
Results: HOPE enrolled 2798 patients from 35 centers in 7 countries. Median age was 67 years (IQR: 53.0-78.0), and most were male (59.5%). A relevant heart disease was present in 682 (24%) cases. These were older, more frequently male, with higher overall burden of cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, smoking habit, obesity) and other comorbidities such renal failure, lung, cerebrovascular disease and oncologic antecedents (p < 0.01, for all). The heart cohort received more corticoids (28.9% vs. 20.4%, p < 0.001), antibiotics, but less hydroxychloroquine, antivirals or tocilizumab. Considering the epidemiologic profile, a previous heart condition was independently related with short-term mortality in the Cox multivariate analysis (1.62; 95% CI 1.29-2.03; p < 0.001). Moreover, heart patients needed more respiratory, circulatory support, and presented more in-hospital events, such heart failure, renal failure, respiratory insufficiency, sepsis, systemic infammatory response syndrome and clinically relevant bleedings (all, p < 0.001), and mortality (39.7% vs. 15.5%; p < 0.001).
Conclusions: An underlying heart disease is an adverse prognostic factor for patients suffering COVID-19. Its presence could be related with different clinical drug management and would benefit from maintaining treatment with angiotensin converting enzyme inhibitors or angiotensin receptor blockers during in-hospital stay.
Thematic Areas: Saúde coletiva Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas ii Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: alfredo.bardaji@urv.cat
Author identifier: 0000-0003-1900-6974
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubmed.ncbi.nlm.nih.gov/33346365/
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cardiology Journal. 28 (2): 202-214
APA: Nunez-Gil, Ivan J.; Fernandez-Ortiz, Antonio; Maroud Eid, Charbel; Huang, Jia; Romero, Rodolfo; Manuel Becerra-Munoz, Victor; Uribarri, Aitor; Feltes, (2021). Underlying heart diseases and acute COVID-19 outcomes. Cardiology Journal, 28(2), 202-214. DOI: 10.5603/CJ.a2020.0183
Article's DOI: 10.5603/CJ.a2020.0183
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications