Articles producció científica> Bioquímica i Biotecnologia

Lipid Profiles and Heart Failure Risk Results From Two Prospective Studies

  • Identification data

    Identifier: imarina:9207270
    Authors:
    Wittenbecher, ClemensEichelmann, FabianToledo, EstefaniaGuasch-Ferre, MartaRuiz-Canela, MiguelLi, JunAros, FernandoLee, Chih-HaoLiang, LimingSalas-Salvado, JordiClish, Clary B.Schulze, Matthias B.Martinez-Gonzalez, Miguel AngelHu, Frank B.
    Abstract:
    RATIONALE: Altered lipid metabolism has been implicated in heart failure (HF) development, but no prospective studies have examined comprehensive lipidomics data and subsequent risk of HF. OBJECTIVE: We aimed to link single lipid metabolites and lipidomics networks to the risk of developing HF. METHODS AND RESULTS: Discovery analyses were based on 216 targeted lipids in a case-control study (331 incident HF cases and 507 controls, matched by age, sex, and study center), nested within the PREDIMED (Prevencion con Dieta Mediterranea) study. Associations of single lipids were examined in conditional logistic regression models. Furthermore, lipidomics networks were linked to HF risk in a multistep workflow, including machine learning-based identification of the HF-related network clusters, and regression-based discovery of the HF-related lipid patterns within these clusters. If available, significant findings were externally validated in a subsample of the EPIC-Potsdam cohort (2414 at-risk participants, including 87 incident HF cases). After confounder-adjustments, 2 lipids were significantly associated with HF risk in both cohorts: CER (ceramide) 16:0 (relative risk [RR] per SD in PREDIMED, 1.28 [95% CI, 1.13-1.47]) and phosphatidylcholine 32_0 (RR per SD in PREDIMED, 1.23 [95% CI, 1.08-1.41]). Additionally, lipid patterns in several network clusters were associated with HF risk in PREDIMED. Adjusted for standard risk factors, an internally cross-validated score based on the significant HF-related lipids that were identified in the network analysis in PREDIMED was associated with a higher HF risk (20 lipids, RR per SD, 2.33 [95% CI, 1.93%-2.81%). Moreover, a lipid score restricted to the externally available lipids was significantly associated with HF incidence in both coh
  • Others:

    Author, as appears in the article.: Wittenbecher, Clemens; Eichelmann, Fabian; Toledo, Estefania; Guasch-Ferre, Marta; Ruiz-Canela, Miguel; Li, Jun; Aros, Fernando; Lee, Chih-Hao; Liang, Liming; Salas-Salvado, Jordi; Clish, Clary B.; Schulze, Matthias B.; Martinez-Gonzalez, Miguel Angel; Hu, Frank B.;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Very elderly Time factors Time factor Risk assessment Randomized controlled trials as topic Randomized controlled trial (topic) Prospective study Prospective studies Prognosis Prevalence Multicenter study Middle aged Metabolism Male Lipids Lipidomics Lipid Incidence Humans Human Heart failure Heart disease risk factors Female Dyslipidemias Dyslipidemia Clinical trial Case-control studies Case control study Blood Biomarkers Biomarker Biological marker Aged, 80 and over Aged Adult
    Abstract: RATIONALE: Altered lipid metabolism has been implicated in heart failure (HF) development, but no prospective studies have examined comprehensive lipidomics data and subsequent risk of HF. OBJECTIVE: We aimed to link single lipid metabolites and lipidomics networks to the risk of developing HF. METHODS AND RESULTS: Discovery analyses were based on 216 targeted lipids in a case-control study (331 incident HF cases and 507 controls, matched by age, sex, and study center), nested within the PREDIMED (Prevencion con Dieta Mediterranea) study. Associations of single lipids were examined in conditional logistic regression models. Furthermore, lipidomics networks were linked to HF risk in a multistep workflow, including machine learning-based identification of the HF-related network clusters, and regression-based discovery of the HF-related lipid patterns within these clusters. If available, significant findings were externally validated in a subsample of the EPIC-Potsdam cohort (2414 at-risk participants, including 87 incident HF cases). After confounder-adjustments, 2 lipids were significantly associated with HF risk in both cohorts: CER (ceramide) 16:0 (relative risk [RR] per SD in PREDIMED, 1.28 [95% CI, 1.13-1.47]) and phosphatidylcholine 32_0 (RR per SD in PREDIMED, 1.23 [95% CI, 1.08-1.41]). Additionally, lipid patterns in several network clusters were associated with HF risk in PREDIMED. Adjusted for standard risk factors, an internally cross-validated score based on the significant HF-related lipids that were identified in the network analysis in PREDIMED was associated with a higher HF risk (20 lipids, RR per SD, 2.33 [95% CI, 1.93%-2.81%). Moreover, a lipid score restricted to the externally available lipids was significantly associated with HF incidence in both cohorts (6 lipids, RRs per SD, 1.30 [95% CI, 1.14-1.47] in PREDIMED, and 1.46 [95% CI, 1.17-1.82] in EPIC-Potsdam). CONCLUSIONS: Our study identified and validated 2 lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF risk. Lipid profiling may capture preclinical molecular alterations that predispose for incident HF.
    Thematic Areas: Saúde coletiva Química Physiology Peripheral vascular disease Nutrição Medicina i Interdisciplinar Hematology General medicine Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.317883
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Circulation Research. 128 (3): 309-320
    APA: Wittenbecher, Clemens; Eichelmann, Fabian; Toledo, Estefania; Guasch-Ferre, Marta; Ruiz-Canela, Miguel; Li, Jun; Aros, Fernando; Lee, Chih-Hao; Liang, (2021). Lipid Profiles and Heart Failure Risk Results From Two Prospective Studies. Circulation Research, 128(3), 309-320. DOI: 10.1161/CIRCRESAHA.120.317883
    Article's DOI: 10.1161/CIRCRESAHA.120.317883
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Hematology,Peripheral Vascular Disease,Physiology
    Very elderly
    Time factors
    Time factor
    Risk assessment
    Randomized controlled trials as topic
    Randomized controlled trial (topic)
    Prospective study
    Prospective studies
    Prognosis
    Prevalence
    Multicenter study
    Middle aged
    Metabolism
    Male
    Lipids
    Lipidomics
    Lipid
    Incidence
    Humans
    Human
    Heart failure
    Heart disease risk factors
    Female
    Dyslipidemias
    Dyslipidemia
    Clinical trial
    Case-control studies
    Case control study
    Blood
    Biomarkers
    Biomarker
    Biological marker
    Aged, 80 and over
    Aged
    Adult
    Saúde coletiva
    Química
    Physiology
    Peripheral vascular disease
    Nutrição
    Medicina i
    Interdisciplinar
    Hematology
    General medicine
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
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