Articles producció científica> Medicina i Cirurgia

Low HDL and high triglycerides predict COVID-19 severity

  • Identification data

    Identifier: imarina:9216322
    Authors:
    Masana, LluisCorreig, EudaldIbarretxe, DaianaAnoro, EvaArroyo, Juan AntonioJerico, CarlosGuerrero, Carolinala Miret, MarcelNaf, SilviaPardo, AnnaPerea, VeronicaPerez-Bernalte, RosaPlana, NuriaRamirez-Montesinos, RafaelRoyuela, MeritxellSoler, CristinaUrquizu-Padilla, MariaZamora, AlbertoPedro-Botet, Juan
    Abstract:
    Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
  • Others:

    Author, as appears in the article.: Masana, Lluis; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jerico, Carlos; Guerrero, Carolina; la Miret, Marcel; Naf, Silvia; Pardo, Anna; Perea, Veronica; Perez-Bernalte, Rosa; Plana, Nuria; Ramirez-Montesinos, Rafael; Royuela, Meritxell; Soler, Cristina; Urquizu-Padilla, Maria; Zamora, Alberto; Pedro-Botet, Juan
    Department: Medicina i Cirurgia
    URV's Author/s: Correig Fraga, Eudald / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Naf Cortés, Silvia Daniela / Plana Gil, Núria / Rodríguez Borjabad, Cèlia
    Keywords: Triglycerides Triacylglycerol Severity of illness index Middle aged Male Lipids Lipid Humans Human Hospitalization High density lipoprotein cholesterol Fibrin fragment d Fibrin fibrinogen degradation products Fibrin degradation product Ferritins Ferritin Female Etiology Covid-19 Cholesterol, hdl Blood Aged
    Abstract: Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: daiana.ibarretxe@urv.cat luis.masana@urv.cat eudald.correig@urv.cat celia.rodriguez@urv.cat silviadaniela.naf@urv.cat eudald.correig@urv.cat celia.rodriguez@urv.cat
    Author identifier: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0001-8160-3716
    Record's date: 2024-08-10
    Journal volume: 11
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-021-86747-5
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 11 (1): 7217-
    APA: Masana, Lluis; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jerico, Carlos; Guerrero, Carolina; la Miret, Marcel; Naf, Silvia (2021). Low HDL and high triglycerides predict COVID-19 severity. Scientific Reports, 11(1), 7217-. DOI: 10.1038/s41598-021-86747-5
    Article's DOI: 10.1038/s41598-021-86747-5
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Triglycerides
    Triacylglycerol
    Severity of illness index
    Middle aged
    Male
    Lipids
    Lipid
    Humans
    Human
    Hospitalization
    High density lipoprotein cholesterol
    Fibrin fragment d
    Fibrin fibrinogen degradation products
    Fibrin degradation product
    Ferritins
    Ferritin
    Female
    Etiology
    Covid-19
    Cholesterol, hdl
    Blood
    Aged
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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