Author, as appears in the article.: Yuste, Silvia; Ludwig, Iziar A.; Romero, Maria-Paz; Pinol-Felis, Carme; Catalan, Ursula; Pedret, Anna; Valls, Rosa M.; Fernandez-Castillejo, Sara; Motilva, Maria-Jose; Macia, Alba; Rubio, Laura;
Department: Medicina i Cirurgia
URV's Author/s: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Pedret Figuerola, Anna / Valls Zamora, Rosa Maria
Keywords: Vitro bio-accessibility Uplc-ms/ms Sustained intake Red-fleshed apple Polyphenols Phenolic compounds Melanocarpa fruit juice In-vitro Extract Dihydrochalcone metabolism Bowman's space Atherosclerosis Aortic thickness Antioxidant activity Anthocyanins Adipose-tissue
Abstract: The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect sobserved after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: ursula.catalan@urv.cat anna.pedret@urv.cat rosamaria.valls@urv.cat
Author identifier: 0000-0001-8884-9823 0000-0002-5327-932X 0000-0002-3351-0942
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202001225
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 65 (10):
APA: Yuste, Silvia; Ludwig, Iziar A.; Romero, Maria-Paz; Pinol-Felis, Carme; Catalan, Ursula; Pedret, Anna; Valls, Rosa M.; Fernandez-Castillejo, Sara; Mot (2021). Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red-Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White-Fleshed Apple: The AppleCOR Study. Molecular Nutrition & Food Research, 65(10), -. DOI: 10.1002/mnfr.202001225
Article's DOI: 10.1002/mnfr.202001225
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV