Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Identifier:  imarina:9216712

Handle: https://hdl.handle.net/20.500.11797/imarina9216712

Authors:  Diaz-Lopez, Andres; Paz-Graniel, Indira; Ruiz, Veronica; Toledo, Estefania; Becerra-Tomas, Nerea; Corella, Dolores; Castaner, Olga; Martinez, J Alfredo; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, Luis; Bueno-Cavanillas, Aurora; Tur, Josep A; Sanchez, Vicente Martin; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Villa, Tania Fernandez; Ros, Emilio; Eguaras, Sonia; Babio, Nancy; Sorli, Jose V; Goday, Albert; Abete, Itziar; Sierra, Lucas Tojal; Baron-Lopez, Francisco Javier; Torres-Collado, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Bernal-Lopez, Maria Rosa; Santos-Lozano, Jose Manuel; Navarro, Adela; Gonzalez, Jose I; Zomeno, Maria Dolores; Zulet, Maria Angeles; Luna, Jessica Vaquero; Ramallal, Raul; Fito, Montse; Salas-Salvado, Jordi

Abstract:
It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m(2) greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m(2) (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m(2) greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.