Articles producció científica> Enginyeria Química

Milestones and current achievements in development of multifunctional bioscaffolds for medical application

  • Identification data

    Identifier: imarina:9216796
    Authors:
    Litowczenko, JagodaWozniak-Budych, Marta J.Staszak, KatarzynaWieszczycka, KarolinaJurga, StefanTylkowski, Bartosz
    Abstract:
    Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or improve lost tissue function. Despite that TE was introduced more than 20 years ago, innovative and more sophisticated trends and technologies point to new challenges and development. Current challenges involve the demand for multifunctional bioscaffolds which can stimulate tissue regrowth by biochemical curves, biomimetic patterns, active agents and proper cell types. For those purposes especially promising are carefully chosen primary cells or stem cells due to its high proliferative and differentiation potential. This review summarized a variety of recently reported advanced bioscaffolds which present new functions by combining polymers, nanomaterials, bioactive agents and cells depending on its desired application. In particular necessity of study biomaterial-cell interactions with in vitro cell culture models, and studies using animals with in vivo systems were discuss to permit the analysis of full material biocompatibility. Although these bioscaffolds have shown a significant therapeutic effect in nervous, cardiovascular and muscle, tissue engineering, there are still many remaining unsolved challenges for scaffolds improvement.
  • Others:

    Author, as appears in the article.: Litowczenko, Jagoda; Wozniak-Budych, Marta J.; Staszak, Katarzyna; Wieszczycka, Karolina; Jurga, Stefan; Tylkowski, Bartosz;
    Department: Enginyeria Química
    URV's Author/s: Tylkowski, Bartosz
    Keywords: Tissue-repair Stem-cells Skeletal-muscle Scaffolds Regenerative medicine Regeneration Innovative materials In-vitro Hydrogels Growth Electrospun nanofibers Drug-delivery systems Biomimetric materials Acid-based scaffolds
    Abstract: Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or improve lost tissue function. Despite that TE was introduced more than 20 years ago, innovative and more sophisticated trends and technologies point to new challenges and development. Current challenges involve the demand for multifunctional bioscaffolds which can stimulate tissue regrowth by biochemical curves, biomimetic patterns, active agents and proper cell types. For those purposes especially promising are carefully chosen primary cells or stem cells due to its high proliferative and differentiation potential. This review summarized a variety of recently reported advanced bioscaffolds which present new functions by combining polymers, nanomaterials, bioactive agents and cells depending on its desired application. In particular necessity of study biomaterial-cell interactions with in vitro cell culture models, and studies using animals with in vivo systems were discuss to permit the analysis of full material biocompatibility. Although these bioscaffolds have shown a significant therapeutic effect in nervous, cardiovascular and muscle, tissue engineering, there are still many remaining unsolved challenges for scaffolds improvement.
    Thematic Areas: Materials science, biomaterials Engineering, biomedical Biotechnology Biomedical engineering Biomaterials
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: bartosz.tylkowski@urv.cat
    Author identifier: 0000-0002-4163-0178
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S2452199X21000116
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bioactive Materials. 6 (8): 2412-2438
    APA: Litowczenko, Jagoda; Wozniak-Budych, Marta J.; Staszak, Katarzyna; Wieszczycka, Karolina; Jurga, Stefan; Tylkowski, Bartosz; (2021). Milestones and current achievements in development of multifunctional bioscaffolds for medical application. Bioactive Materials, 6(8), 2412-2438. DOI: 10.1016/j.bioactmat.2021.01.007
    Article's DOI: 10.1016/j.bioactmat.2021.01.007
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biomaterials,Biomedical Engineering,Biotechnology,Engineering, Biomedical,Materials Science, Biomaterials
    Tissue-repair
    Stem-cells
    Skeletal-muscle
    Scaffolds
    Regenerative medicine
    Regeneration
    Innovative materials
    In-vitro
    Hydrogels
    Growth
    Electrospun nanofibers
    Drug-delivery systems
    Biomimetric materials
    Acid-based scaffolds
    Materials science, biomaterials
    Engineering, biomedical
    Biotechnology
    Biomedical engineering
    Biomaterials
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