Author, as appears in the article.: Litowczenko, Jagoda; Wozniak-Budych, Marta J; Staszak, Katarzyna; Wieszczycka, Karolina; Jurga, Stefan; Tylkowski, Bartosz
Department: Enginyeria Química
URV's Author/s: Tylkowski, Bartosz
Keywords: Tissue-repair Stem-cells Skeletal-muscle Scaffolds Regenerative medicine Regeneration Innovative materials In-vitro Hydrogels Growth Electrospun nanofibers Drug-delivery systems Biomimetric materials Acid-based scaffolds
Abstract: Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or improve lost tissue function. Despite that TE was introduced more than 20 years ago, innovative and more sophisticated trends and technologies point to new challenges and development. Current challenges involve the demand for multifunctional bioscaffolds which can stimulate tissue regrowth by biochemical curves, biomimetic patterns, active agents and proper cell types. For those purposes especially promising are carefully chosen primary cells or stem cells due to its high proliferative and differentiation potential. This review summarized a variety of recently reported advanced bioscaffolds which present new functions by combining polymers, nanomaterials, bioactive agents and cells depending on its desired application. In particular necessity of study biomaterial-cell interactions with in vitro cell culture models, and studies using animals with in vivo systems were discuss to permit the analysis of full material biocompatibility. Although these bioscaffolds have shown a significant therapeutic effect in nervous, cardiovascular and muscle, tissue engineering, there are still many remaining unsolved challenges for scaffolds improvement.
Thematic Areas: Materials science, biomaterials Engineering, biomedical Ciencias sociales Biotechnology Biomedical engineering Biomaterials
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: bartosz.tylkowski@urv.cat
Author identifier: 0000-0002-4163-0178
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Bioactive Materials. 6 (8): 2412-2438
APA: Litowczenko, Jagoda; Wozniak-Budych, Marta J; Staszak, Katarzyna; Wieszczycka, Karolina; Jurga, Stefan; Tylkowski, Bartosz (2021). Milestones and current achievements in development of multifunctional bioscaffolds for medical application. Bioactive Materials, 6(8), 2412-2438. DOI: 10.1016/j.bioactmat.2021.01.007
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV