Articles producció científica> Bioquímica i Biotecnologia

Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial

  • Identification data

    Identifier: imarina:9216837
  • Authors:

    Becerra-Tomas, Nerea
    Ruiz-Canela, Miguel
    Hernandez-Alonso, Pablo
    Bullo, Monica
    Li, Jun
    Guasch-Ferre, Marta
    Toledo, Estefania
    Clish, Clary B.
    Estruch, Ramon
    Ros, Emilio
    Fito, Montserrat
    Lee, Chih-Hao
    Pierce, Kerry
    Aros, Fernando
    Serra-Majem, Lluis
    Liang, Liming
    Razquin, Cristina
    Gomez-Gracia, Enrique
    Martinez-Gonzalez, Miguel A.
    Hu, Frank B.
    Corella, Dolores
    Salas-Salvado, Jordi
  • Others:

    Author, as appears in the article.: Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Hernandez-Alonso, Pablo; Bullo, Monica; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary B.; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Lee, Chih-Hao; Pierce, Kerry; Aros, Fernando; Serra-Majem, Lluis; Liang, Liming; Razquin, Cristina; Gomez-Gracia, Enrique; Martinez-Gonzalez, Miguel A.; Hu, Frank B.; Corella, Dolores; Salas-Salvado, Jordi;
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2218-1989
    URV's Author/s: Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Keywords: Uric-acid Predimed study Heart failure Glycolysis Glucose Biomarkers Atrial fibrillation
    Abstract: The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case-control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR (for 1 SD increase): 1.28; 95% CI: 1.06, 1.53). The present findings do not support a role of the glycolysis pathway in the pathogenesis of AF. However, the increased risk of HF associated with phosphoglycerate requires further studies.
    Thematic Areas: Molecular biology Medicina ii Farmacia Endocrinology, diabetes and metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nerea.becerra@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-07-27
    Journal volume: 11
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2218-1989/11/5/306
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Metabolites. 11 (5):
    APA: Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Hernandez-Alonso, Pablo; Bullo, Monica; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary B.; E (2021). Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites, 11(5), -. DOI: 10.3390/metabo11050306
    Article's DOI: 10.3390/metabo11050306
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Endocrinology, Diabetes and Metabolism,Molecular Biology
    Uric-acid
    Predimed study
    Heart failure
    Glycolysis
    Glucose
    Biomarkers
    Atrial fibrillation
    Molecular biology
    Medicina ii
    Farmacia
    Endocrinology, diabetes and metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
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