Author, as appears in the article.: Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Hernandez-Alonso, Pablo; Bullo, Monica; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary B.; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Lee, Chih-Hao; Pierce, Kerry; Aros, Fernando; Serra-Majem, Lluis; Liang, Liming; Razquin, Cristina; Gomez-Gracia, Enrique; Martinez-Gonzalez, Miguel A.; Hu, Frank B.; Corella, Dolores; Salas-Salvado, Jordi;

Department: Bioquímica i Biotecnologia

e-ISSN: 2218-1989

URV's Author/s: Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge

Keywords: Uric-acid Predimed study Heart failure Glycolysis Glucose Biomarkers Atrial fibrillation

Abstract: The increased prevalence of atrial fibrillation (AF) and heart failure (HF) highlights the need to better understand the mechanisms underlying these cardiovascular diseases (CVDs). In the present study, we aimed to evaluate the association between glycolysis-related metabolites and the risk of AF and HF in a Mediterranean population at high risk of CVD. We used two case-control studies nested within the PREDIMED trial. A total of 512 incident AF cases matched to 734 controls, and 334 incident HF cases matched to 508 controls, were included. Plasma metabolites were quantified by using hydrophilic interaction liquid chromatography coupled with high-resolution negative ion mode MS detection. Conditional logistic regression analyses were performed. The results showed no association between baseline plasma glycolysis intermediates and other related metabolites with AF. Only phosphoglycerate was associated with a higher risk of HF (OR (for 1 SD increase): 1.28; 95% CI: 1.06, 1.53). The present findings do not support a role of the glycolysis pathway in the pathogenesis of AF. However, the increased risk of HF associated with phosphoglycerate requires further studies.

Thematic Areas: Molecular biology Medicina ii Farmacia Endocrinology, diabetes and metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: nerea.becerra@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat

Author identifier: 0000-0002-4429-6507 0000-0003-2700-7459 0000-0002-0218-7046

Record's date: 2023-09-02

Journal volume: 11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2218-1989/11/5/306

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Metabolites. 11 (5):

APA: Becerra-Tomas, Nerea; Ruiz-Canela, Miguel; Hernandez-Alonso, Pablo; Bullo, Monica; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary B.; E (2021). Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial. Metabolites, 11(5), -. DOI: 10.3390/metabo11050306

Article's DOI: 10.3390/metabo11050306

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications