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Human biomonitoring of bisphenol A along pregnancy: An exposure reconstruction of the EXHES-Spain cohort

  • Identification data

    Identifier: imarina:9216854
    Authors:
    Martinez, Maria AngelesGonzalez, NeusMarti, AnnaMarques, MontseRovira, JoaquimKumar, VikasNadal, Marti
    Abstract:
    This study was aimed at reconstructing the exposure to bisphenol (BPA) of 60 pregnant women from the EXHESSpain cohort. A biomonitoring study was conducted by determining BPA levels in urine samples over the three trimesters of pregnancy. Moreover, the correlations between BPA levels and the role of different potential exposure sources, with special emphasis on the dietary intake, were also studied. Urine samples were subjected to dispersive liquid-liquid microextraction and the subsequent analysis via gas chromatography-mass spectrometry. BPA was detected in 76% of the urine samples. A significant decrease of urinary BPA levels was observed along pregnancy, as mean concentrations of creatinine-adjusted BPA were 4.64, 4.84 and 2.51 ?g/g in the first, second and third trimester, respectively. This decrease was essentially associated with changes in the dietary habits of the pregnant women, including a lower intake of canned food and drinks. However, the potential role of other pregnancy-related biochemical or physiological factors should not be disregarded. Very interestingly, significant differences in urine BPA levels were found according to the fruit consumption pattern, as women who ate more citrus fruits showed lower BPA concentrations in urine. The reconstructed exposure to BPA was estimated in 0.072, 0.069 and 0.038 ?g BPA/kg of body weight/day in the first, second and third trimesters, respectively. These values are far below the temporary tolerable daily intake (t-TDI) established by the EFSA.
  • Others:

    Author, as appears in the article.: Martinez, Maria Angeles; Gonzalez, Neus; Marti, Anna; Marques, Montse; Rovira, Joaquim; Kumar, Vikas; Nadal, Marti;
    Department: Ciències Mèdiques Bàsiques Enginyeria Química Bioquímica i Biotecnologia
    URV's Author/s: Gonzalez Paradell, Nieves / Kumar, Vikas / Marquès Bueno, Montserrat / Martí Zaragoza, Àlex / Martínez Rodríguez, María Ángeles / Nadal Lomas, Martí / Rovira Solano, Joaquim
    Keywords: Variability Urine sampling Urine level Urine concentrations Urine Tolerable daily intake Third trimester pregnancy Spain Second trimester pregnancy Sampling Reconstruction Priority journal Prenatal exposure Pregnant women Pregnant woman Pregnancy Predictors Physiology Phenols Phenol derivative Mothers Measurement accuracy Mass fragmentography Liquid phase microextraction Limit of quantitation Limit of detection Humans Human Health survey Fruit consumption Food First trimester pregnancy Fetal-growth Female Exposure reconstruction Estimation method Eating habit Dietary intake Dietary exposure Data analysis software Creatinine Controlled study Concentration (composition) Cohort analysis Citrus fruit Citrus Canned food Bpa Body weight Bisphenol a Birth-weight Biomonitoring Biological monitoring Biochemistry Benzhydryl derivative Benzhydryl compounds Article Adult 4,4' isopropylidenediphenol
    Abstract: This study was aimed at reconstructing the exposure to bisphenol (BPA) of 60 pregnant women from the EXHESSpain cohort. A biomonitoring study was conducted by determining BPA levels in urine samples over the three trimesters of pregnancy. Moreover, the correlations between BPA levels and the role of different potential exposure sources, with special emphasis on the dietary intake, were also studied. Urine samples were subjected to dispersive liquid-liquid microextraction and the subsequent analysis via gas chromatography-mass spectrometry. BPA was detected in 76% of the urine samples. A significant decrease of urinary BPA levels was observed along pregnancy, as mean concentrations of creatinine-adjusted BPA were 4.64, 4.84 and 2.51 ?g/g in the first, second and third trimester, respectively. This decrease was essentially associated with changes in the dietary habits of the pregnant women, including a lower intake of canned food and drinks. However, the potential role of other pregnancy-related biochemical or physiological factors should not be disregarded. Very interestingly, significant differences in urine BPA levels were found according to the fruit consumption pattern, as women who ate more citrus fruits showed lower BPA concentrations in urine. The reconstructed exposure to BPA was estimated in 0.072, 0.069 and 0.038 ?g BPA/kg of body weight/day in the first, second and third trimesters, respectively. These values are far below the temporary tolerable daily intake (t-TDI) established by the EFSA.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: marti.nadal@urv.cat nieves.gonzalez@urv.cat vikas.kumar@urv.cat montserrat.marques@urv.cat mangeles.martinez@urv.cat joaquim.rovira@urv.cat alex.marti@estudiants.urv.cat marti.nadal@urv.cat
    Author identifier: 0000-0002-0217-4827 0000-0003-4134-016X 0000-0002-9795-5967 0000-0001-6302-8578 0000-0001-8595-3772 0000-0003-4399-6138 0000-0002-0217-4827
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0013935121002358?via%3Dihub#!
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Environmental Research. 196 (110941): 110941-
    APA: Martinez, Maria Angeles; Gonzalez, Neus; Marti, Anna; Marques, Montse; Rovira, Joaquim; Kumar, Vikas; Nadal, Marti; (2021). Human biomonitoring of bisphenol A along pregnancy: An exposure reconstruction of the EXHES-Spain cohort. Environmental Research, 196(110941), 110941-. DOI: 10.1016/j.envres.2021.110941
    Article's DOI: 10.1016/j.envres.2021.110941
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Variability
    Urine sampling
    Urine level
    Urine concentrations
    Urine
    Tolerable daily intake
    Third trimester pregnancy
    Spain
    Second trimester pregnancy
    Sampling
    Reconstruction
    Priority journal
    Prenatal exposure
    Pregnant women
    Pregnant woman
    Pregnancy
    Predictors
    Physiology
    Phenols
    Phenol derivative
    Mothers
    Measurement accuracy
    Mass fragmentography
    Liquid phase microextraction
    Limit of quantitation
    Limit of detection
    Humans
    Human
    Health survey
    Fruit consumption
    Food
    First trimester pregnancy
    Fetal-growth
    Female
    Exposure reconstruction
    Estimation method
    Eating habit
    Dietary intake
    Dietary exposure
    Data analysis software
    Creatinine
    Controlled study
    Concentration (composition)
    Cohort analysis
    Citrus fruit
    Citrus
    Canned food
    Bpa
    Body weight
    Bisphenol a
    Birth-weight
    Biomonitoring
    Biological monitoring
    Biochemistry
    Benzhydryl derivative
    Benzhydryl compounds
    Article
    Adult
    4,4' isopropylidenediphenol
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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