Author, as appears in the article.: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T.; Sjodin, Anders; Harrold, Joanne A.; Halford, Jason C. G.; Bullo, Monica;

Department: Bioquímica i Biotecnologia

URV's Author/s: Bulló Bonet, Mònica

Keywords: Satin Obesity Metabolomics Lean mass Insulin-resistance Fat mass Disease Body composition

Abstract: The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes.

Thematic Areas: Molecular biology Medicina ii Farmacia Endocrinology, diabetes and metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: monica.bullo@urv.cat

Author identifier: 0000-0002-0218-7046

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2218-1989/11/5/317

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Metabolites. 11 (5):

APA: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T.; Sjodin, Anders; Harrold, Joanne A.; Halford, Jason C. G.; Bull (2021). Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity. Metabolites, 11(5), -. DOI: 10.3390/metabo11050317

Article's DOI: 10.3390/metabo11050317

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications