Articles producció científica> Bioquímica i Biotecnologia

Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity

  • Identification data

    Identifier: imarina:9216858
    Authors:
    Papandreou, ChristopherGarcia-Gavilan, JesusCamacho-Barcia, LuciaHansen, Thea TSjodin, AndersHarrold, Joanne AHalford, Jason C GBullo, Monica
    Abstract:
    The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes.
  • Others:

    Author, as appears in the article.: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T; Sjodin, Anders; Harrold, Joanne A; Halford, Jason C G; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / García Gavilán, Jesús Francisco
    Keywords: Satin Satiety innovation (satin) Obesity Metabolomics Lean mass Insulin-resistance Fat mass Disease Body composition
    Abstract: The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes.
    Thematic Areas: Molecular biology Medicina ii Farmacia Endocrinology, diabetes and metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat monica.bullo@urv.cat
    Author identifier: 0000-0002-0218-7046
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2218-1989/11/5/317
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Metabolites. 11 (5): 317-
    APA: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Hansen, Thea T; Sjodin, Anders; Harrold, Joanne A; Halford, Jason C G; Bullo, M (2021). Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity. Metabolites, 11(5), 317-. DOI: 10.3390/metabo11050317
    Article's DOI: 10.3390/metabo11050317
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Endocrinology, Diabetes and Metabolism,Molecular Biology
    Satin
    Satiety innovation (satin)
    Obesity
    Metabolomics
    Lean mass
    Insulin-resistance
    Fat mass
    Disease
    Body composition
    Molecular biology
    Medicina ii
    Farmacia
    Endocrinology, diabetes and metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry & molecular biology
    Biochemistry
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